Silicon-based Tetrahydrocannabinol Derivatives and Compositions Thereof
, 2022 Silicon-based tetrahydrocannabinol derivatives and methods for their synthesis are provided, in which the derivatives contain a tetrahydrocannabinol molecule and at least one silicon-based group containing Si--O--Si bonds.
Arkles, Barry +3 more
core +1 more source
The tetrahydrocannabinol and tetrahydrocannabinolic acid content of cannabis products
Journal of Pharmacy and Pharmacology, 1981 Abstract Cannabinoid acids readily decarboxylate to the corresponding cannabinoid. Methods are available for the determination of Δ9-tetrahydrocannabinol (THC) and its acids (THCA) and published data on the levels of these compounds in cannabis are summarized.
P B, Baker, B J, Taylor, T A, Gough
openaire +2 more sources
EVALI Vaping Liquids Part 1: GC-MS Cannabinoids Profiles and Identification of Unnatural THC Isomers
Frontiers in Chemistry, 2021 Tetrahydrocannabinol (THC)-containing products played a major role in the 2019 US nationwide outbreak of pulmonary lung illness associated with e-cigarettes or vaping liquids (EVALI).
Laura A. Ciolino +4 more
doaj +1 more source
Investigating the cumulative effects of Δ9-tetrahydrocannabinol and repetitive mild traumatic brain injury on adolescent rats [PDF]
, 2020 The prevalence of mild traumatic brain injury is highest amongst the adolescent population and can lead to complications including neuroinflammation and excitotoxicity. Also pervasive in adolescents is recreational cannabis use.
Hazari, A +6 more
core +1 more source
Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow. [PDF]
, 2022 Microbial production of cannabinoids promises to provide a consistent, cheaper, and more sustainable supply of these important therapeutic molecules. However, scaling production to compete with traditional plant-based sources is challenging.
Ladds, Graham +6 more
core +10 more sources
Frontiers in Neuroscience, 2023 Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3–4 orders of magnitude
Guy Shapira +10 more
doaj +1 more source
The Diels‐Alder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC) [PDF]
, 2021 Based on the Diels-Alder reaction of vinylchromenes with electron-poor dienophiles, we developed a strategy for the synthesis of tetrahydrocannabinol derivatives.
Glaeser, Franziska +12 more
core +2 more sources
Royal Society Open Science, 2022 Demand for cannabinoid is growing, with the global market expected to reach $9.69 billion by 2025. Understanding how chemical composition changes in hemp at different harvest times is crucial to maximizing this industrial crop value.
Pakin Noppawan +6 more
doaj +1 more source
Determination of the Cross-Reactivity of the Biological Metabolite (-)-trans-Δ9-Tetrahydrocannabinol-Carboxylic Acid-Glucuronide (THC-COOH-Gluc) for Cannabinoid Immunoassays. [PDF]
, 2021 The highest concentrated metabolite of (-)-trans-Δ9-tetrahydrocannabinol (THC) in urine, the main psychoactive constituent of Cannabis sativa, is 11-nor-9-carboxy-(-)-trans-Δ9-tetrahydrocannabinol-β-D-glucuronide [(-)-trans-THC-COOH-Gluc].
Weinmann, Wolfgang +1 more
core +2 more sources
Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA
Angewandte Chemie, EarlyView.The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch +2 more
wiley +2 more sources