Results 21 to 30 of about 20,460 (225)

Time Trends of Tetrahydrocannabinol (THC) in a 2008–2021 German National Survey of Hemp Food Products

Foods, 2022
∆9-Tetrahydrocannabinol (THC) is known as the main psychotropic compound present in the hemp plant. It also occurs in commercially available hemp food products and may have adverse effects on consumers.
Hannah Dräger, Ines Barthlott, Patricia Golombek, Stephan G. Walch, Dirk W. Lachenmeier   +4 more
doaj   +1 more source

In the Swim of Cannabis: Developmental Toxicity and Metabolomic Pathway Alterations of Zebrafish Larvae Exposed to THC for the Assessment of Its Potential Environmental and Human Health Impact

Molecules, 2022
As the pharmacological properties and therapeutic applications of Cannabis sativa L. pace with the upsurge of interest of the scientific community in harnessing its constituent phytocannabinoids, illicit use may raise serious health issues ...
Theodoros Chatzimitakos, Ieremias Chousidis, Dimitrios Leonardos, Constantine Stalikas, Ioannis Leonardos   +4 more
doaj   +1 more source

Sex Differences in Tolerance to Delta-9-Tetrahydrocannabinol in Mice With Cisplatin-Evoked Chronic Neuropathic Pain

Frontiers in Molecular Biosciences, 2021
Tolerance to the pain-relieving effects of cannabinoids limits the therapeutic potential of these drugs in patients with chronic pain. Recent preclinical research with rodents and clinical studies in humans has suggested important differences between ...
Angela N. Henderson-Redmond, Angela N. Henderson-Redmond, Angela N. Henderson-Redmond, LaTaijah C. Crawford, LaTaijah C. Crawford, Diana E. Sepulveda, Diana E. Sepulveda, David E. Hale, Julia J. Lesperance, Daniel J. Morgan, Daniel J. Morgan, Daniel J. Morgan, Daniel J. Morgan   +12 more
doaj   +1 more source

Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Emotion, Cognition, and Attention: A Double-Blind, Placebo-Controlled, Randomized Experimental Trial in Healthy Volunteers

Frontiers in Psychiatry, 2020
The two main phytocannabinoids—delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)—have been extensively studied, and it has been shown that THC can induce transient psychosis. At the same time, CBD appears to have no psychotomimetic potential.
Timo Woelfl, Cathrin Rohleder, Cathrin Rohleder, Juliane K. Mueller, Juliane K. Mueller, Bettina Lange, Anne Reuter, Anna Maria Schmidt, Dagmar Koethe, Dagmar Koethe, Martin Hellmich, F. Markus Leweke, F. Markus Leweke   +12 more
doaj   +1 more source

Transcriptome assemblies for two drug-type cannabis chemotypes by long-read RNA sequencing. [PDF]

Plant Genome
Abstract Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular trichomes—primarily the cannabinoids ∆9‐tetrahydrocannabinol (THC) and cannabidiol (CBD)—has ...
Berkowitz O, Jost R, Ng S, Bacic A, Whelan J, Lewsey MG.   +5 more
europepmc   +2 more sources

EVALI Vaping Liquids Part 1: GC-MS Cannabinoids Profiles and Identification of Unnatural THC Isomers

Frontiers in Chemistry, 2021
Tetrahydrocannabinol (THC)-containing products played a major role in the 2019 US nationwide outbreak of pulmonary lung illness associated with e-cigarettes or vaping liquids (EVALI).
Laura A. Ciolino, Tracy L. Ranieri, Jana L. Brueggemeyer, Allison M. Taylor, Angela S. Mohrhaus   +4 more
doaj   +1 more source

Tetrahydrocannabinols

Cancer and Metastasis Reviews, 2023
Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for controlling cell survival and proliferation as well as psychoactive effects. Most tumor cells express a much higher level of CB1 and CB2; THCs have been investigated as potential cancer therapeutic due to their ...
Prateeksha, Prateeksha, Sharma, Vivek K., Singh, Shiv M., Sharma, Minaxi, Diwan, Deepti, Hesham, Abd El Latif, Guleria, Sanjay, Nguyen, Quang D., Gupta, Vijai K., Singh, Brahma N.   +9 more
openaire   +1 more source

Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice

Frontiers in Neuroscience, 2023
Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound of the cannabis plant and an exogenous ligand of the endocannabinoid system. In previous studies, we demonstrated that a single microdose of THC (0.002 mg/kg, 3–4 orders of magnitude
Guy Shapira, Guy Shapira, Ifat Israel-Elgali, Ifat Israel-Elgali, Meitar Grad, Eden Avnat, Lital Rachmany, Yosef Sarne, Noam Shomron, Noam Shomron, Noam Shomron   +10 more
doaj   +1 more source

Effect of harvest time on the compositional changes in essential oils, cannabinoids, and waxes of hemp (Cannabis sativa L.)

Royal Society Open Science, 2022
Demand for cannabinoid is growing, with the global market expected to reach $9.69 billion by 2025. Understanding how chemical composition changes in hemp at different harvest times is crucial to maximizing this industrial crop value.
Pakin Noppawan, Camille Bainier, Alexandra Lanot, Simon McQueen-Mason, Nontipa Supanchaiyamat, Thomas M. Attard, Andrew J. Hunt   +6 more
doaj   +1 more source

The tetrahydrocannabinol and tetrahydrocannabinolic acid content of cannabis products

Journal of Pharmacy and Pharmacology, 1981
Abstract Cannabinoid acids readily decarboxylate to the corresponding cannabinoid. Methods are available for the determination of Δ9-tetrahydrocannabinol (THC) and its acids (THCA) and published data on the levels of these compounds in cannabis are summarized.
P B, Baker, B J, Taylor, T A, Gough
openaire   +2 more sources