Results 101 to 110 of about 53,819 (266)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The geriatric canon

Monaldi Archives for Chest Disease, 2019
Over the years Geriatrics and gerontology have developed a language shared by most clinicians and researchers who unequivocally defines the health conditions of aging people: one could speak of "geriatric canon", i.e. the set of fundamentals (paradigms, principles, standard reference vocabulary) of geriatric knowledge, the heritage from which they draw
openaire   +4 more sources

Automated chest CT three-dimensional quantification of body composition: adipose tissue and paravertebral muscle

Scientific Reports
This retrospective study developed an automated algorithm for 3D segmentation of adipose tissue and paravertebral muscle on chest CT using artificial intelligence (AI) and assessed its feasibility.
Akinori Hata, Yohei Muraguchi, Minoru Nakatsugawa, Xinan Wang, Jiyeon Song, Noriaki Wada, Takuya Hino, Kota Aoyagi, Masami Kawagishi, Takuo Negishi, Vladimir I. Valtchinov, Mizuki Nishino, Akihiro Koga, Naoki Sugihara, Masahiro Ozaki, Gary M. Hunninghake, Noriyuki Tomiyama, Mark L. Schiebler, Yi Li, David C. Christiani, Hiroto Hatabu   +20 more
doaj   +1 more source

Automatic tricuspid valve annulus extraction and measurement from computed tomography images

Informatics in Medicine Unlocked
Background and objective: Tricuspid regurgitation (TR) is one of the most common forms of valvular heart diseases. The morphological information of the tricuspid valve annulus (TVA) is critical in treatment planning for TR. It is necessary to extract the
Gakuto Aoyama, Zhexin Zhou, Longfei Zhao, Shun Zhao, Keitaro Kawashima, James V. Chapman, Masahiko Asami, Yui Nozaki, Shinichiro Fujimoto, Takuya Sakaguchi   +9 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Legal determinants for running a parish based economic activity

Kościół i Prawo, 2013
Celem artykułu było ukazanie uwarunkowań prawnych parafii w zakresie wykonywania działalności gospodarczej. Parafia na mocy art. 32 i 20 Konstytucji RP, art. 4 ust. 2 Konkordatu oraz art. 55 ust. 3 ustawy o stosunku Państwa do Kościoła Katolickiego w RP,
Paweł Kaleta
doaj  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Cardiac-induced motion of the pancreas and its effect on image quality of ultrahigh-resolution CT

European Radiology Experimental
Recent advancements in diagnostic CT detector technology have made it possible to resolve anatomical features smaller than 20 LP/cm, referred to as ultra-high-resolution (UHR) CT.
Thomas Wesley Holmes, Zhou Yu, Richard Thompson, John N. Oshinski, Amir Pourmorteza   +4 more
doaj   +1 more source