Results 131 to 140 of about 623,585 (307)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

[Review of] Ann Allen Shockley, ed. Afro-American Women Writers: 1746-1933. An Anthology and Critical Guide [PDF]

, 1991
Despite almost four hundred years of racism, sexism and classism, Afro-American women have managed to sustain contact with their creative muses and with the needs and aspirations of their people.
Young, Mary
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Automated chest CT three-dimensional quantification of body composition: adipose tissue and paravertebral muscle

Scientific Reports
This retrospective study developed an automated algorithm for 3D segmentation of adipose tissue and paravertebral muscle on chest CT using artificial intelligence (AI) and assessed its feasibility.
Akinori Hata, Yohei Muraguchi, Minoru Nakatsugawa, Xinan Wang, Jiyeon Song, Noriaki Wada, Takuya Hino, Kota Aoyagi, Masami Kawagishi, Takuo Negishi, Vladimir I. Valtchinov, Mizuki Nishino, Akihiro Koga, Naoki Sugihara, Masahiro Ozaki, Gary M. Hunninghake, Noriyuki Tomiyama, Mark L. Schiebler, Yi Li, David C. Christiani, Hiroto Hatabu   +20 more
doaj   +1 more source

On canonical antichains

Discrete Mathematics, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Setting the canon, translating the canon

Chronotopos, 2020
The second half of the nineteenth century is of crucial importance in Slovene history, as during this time, a sense of national consciousness began to be disseminated, literacy increased significantly, and different Slovene vernaculars were developed into a modern, supra-regional, standardized, and codified Slovene language.
openaire   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Canonical coordinates on the canonical lift

, 2005
In this article we prove the existence of a canonical theta structure for the canonical lift of an ordinary abelian variety.
openaire   +2 more sources