Results 41 to 50 of about 618,228 (285)

Identification of Circulating Gene Expression Signatures of Intracranial Aneurysm in Peripheral Blood Mononuclear Cells

Diagnostics, 2021
Peripheral blood mononuclear cells (PBMCs) play an important role in the inflammation that accompanies intracranial aneurysm (IA) pathophysiology. We hypothesized that PBMCs have different transcriptional profiles in patients harboring IAs as compared to
Vincent M. Tutino, Haley R. Zebraski, Hamidreza Rajabzadeh-Oghaz, Muhammad Waqas, James N. Jarvis, Konrad Bach, Maxim Mokin, Kenneth V. Snyder, Adnan H. Siddiqui, Kerry E. Poppenberg   +9 more
doaj   +1 more source

Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms

Journal of Translational Medicine, 2018
Background Intracranial aneurysms (IAs) are dangerous because of their potential to rupture and cause deadly subarachnoid hemorrhages. Previously, we found significant RNA expression differences in circulating neutrophils between patients with unruptured
Vincent M. Tutino, Kerry E. Poppenberg, Lu Li, Hussain Shallwani, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Hui Meng   +11 more
doaj   +1 more source

Design and Optimization of a Twisted Photodiode Pixel Structure for All-Directional Phase-Detection Autofocus CMOS Image Sensors

Sensors
To achieve an all-directional and high-speed, high-accuracy autofocus (AF) function, we propose a CMOS image sensor with a Twisted Photodiode (PD) structure.
Daiki Shirahige, Koichi Fukuda, Hajime Ikeda, Yusuke Onuki, Ginjiro Toyoguchi, Kohei Okamoto, Shunichi Wakashima, Hiroshi Sekine, Shuhei Hayashi, Ryo Yoshida, Junji Iwata, Yasushi Matsuno, Katsuhito Sakurai, Hiroshi Yuzurihara, Takeshi Ichikawa   +14 more
doaj   +1 more source

Canonical and Non-Canonical Notch Ligands [PDF]

, 2010
Notch signaling induced by canonical Notch ligands is critical for normal embryonic development and tissue homeostasis through the regulation of a variety of cell fate decisions and cellular processes. Activation of Notch signaling is normally tightly controlled by direct interactions with ligand-expressing cells, and dysregulated Notch signaling is ...
Brendan, D'Souza, Laurence, Meloty-Kapella, Gerry, Weinmaster   +2 more
openaire   +2 more sources

Development of 3D-Stacked 1Megapixel Dual-Time-Gated SPAD Image Sensor with Simultaneous Dual Image Output Architecture for Efficient Sensor Fusion

Sensors
Sensor fusion is crucial in numerous imaging and sensing applications. Integrating data from multiple sensors with different field-of-view, resolution, and frame timing poses substantial computational overhead.
Kazuma Chida, Kazuhiro Morimoto, Naoki Isoda, Hiroshi Sekine, Tomoya Sasago, Yu Maehashi, Satoru Mikajiri, Kenzo Tojima, Mahito Shinohara, Ayman T. Abdelghafar, Hiroyuki Tsuchiya, Kazuma Inoue, Satoshi Omodani, Alice Ehara, Junji Iwata, Tetsuya Itano, Yasushi Matsuno, Katsuhito Sakurai, Takeshi Ichikawa   +18 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Computed Tomography Radiomic Signatures Associated With Neutrophil Extracellular Trap Enrichment and First‐Pass Outcome in Ischemic Stroke Thrombi

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Radiomic and transcriptomic analyses have independently identified features linked to mechanical thrombectomy (MT) outcomes. Here, we integrated paired radiomics/transcriptomics of stroke clots to identify neutrophil extracellular trap (NET ...
Briana A. Santo, Tatsat R. Patel, Seyyed M. Mousavi Janbeh Sarayi, Kerry E. Poppenberg, Sarah Balghonaim, Alexandria Scotti, TaJania D. Jenkins, Vinay Jaikumar, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Vincent M. Tutino   +11 more
doaj   +1 more source

The Canon(s) of Constitutional Law: An Introduction [PDF]

, 2000
Any discipline has a canon, a set of themes that organize the way in which people think about the discipline. Or, perhaps, any discipline has a number of competing canons. Is there a canon of constitutional law?
Tushnet, Mark V.
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Morgan's canon, Garner's phonograph, and the evolutionary origins of language and reason [PDF]

, 2000
`Morgan's canon' is a rule for making inferences from animal behaviour about animal minds, proposed in 1892 by the Bristol geologist and zoologist C. Lloyd Morgan, and celebrated for promoting scepticism about the reasoning powers of animals.
Radick, G.
core   +1 more source