Results 51 to 60 of about 53,819 (266)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
CANONICAL AND -CANONICAL MODULES OF A NOETHERIAN ALGEBRA [PDF]
Nagoya Mathematical Journal, 2016 We define canonical and $n$-canonical modules of a module-finite algebra over a Noether commutative ring and study their basic properties. Using $n$-canonical modules, we generalize a theorem on $(n,C)$-syzygy by Araya and Iima which generalize a well-known theorem on syzygies by Evans and Griffith.
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Canonical extensions and canonicity via dcpo presentations
Theoretical Computer Science, 2011 17 pages.
Gehrke, M., Vosmaer, J.
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
ON CANONICAL CONSTRUCTIONS. II [PDF]
Proceedings of the National Academy of Sciences, 1955 In the second paper in this series [2; 3], it was demonstrated that under suitable topological conditions on a space S (which are in particular always satisfied for a manifold), the problem of reconstructing S from its group G of homeomorphism onto itself may be reduced to the problem of reconstructing the points of S from G.
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Physical Review Letters, 2006 It is well known that a system, S, weakly coupled to a heat bath, B, is described by the canonical ensemble when the composite, S+B, is described by the microcanonical ensemble corresponding to a suitable energy shell. This is true both for classical distributions on the phase space and for quantum density matrices.
GOLDSTEIN S +3 more
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The Clementines Dispendiosam and Saepe Contingit and the Evolution of the Medieval Summary Procedure
Journal on European History of Law, 2019 This article intends to explore briefly the steps that lead to the appearance of the summary Rite on the medieval Ius Commune, highlighting the role of Canon law, and in particular the legislative interventions of Pope Clement V, in the conformation of ...
Javier Belda Iniesta, Michela Coretti
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Journal of Translational Medicine, 2020 Background Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptured IAs and trained machine ...
Kerry E. Poppenberg +13 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source