Results 51 to 60 of about 623,585 (307)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Journal of Symbolic Logic, 2009 AbstractWe develop canonical rules capable of axiomatizing all systems of multiple-conclusion rules overK4 orIPC, by extension of the method of canonical formulas by Zakharyaschev [37]. We use the framework to give an alternative proof of the known analysis of admissible rules in basic transitive logics, which additionally yields the following ...
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tribology Online, 2008 In order to improve the lubrication properties of silicon carbide (SiC) in water, symmetrically spiral periodic structures for bi-directional rotation were intermittently and alternately produced on the surface.
Kosuke Kawahara +2 more
doaj +1 more source
Legal Classics: After Deconstructing the Legal Canon [PDF]
, 1994 The debate over the canon has gripped the University in recent years. Defenders of the canon argue that canonical texts embody timeless and universal themes, but critics argue that the process of canonization subordinates certain people and viewpoints ...
Mootz, Francis J., III
core +2 more sources
CANONICAL AND -CANONICAL MODULES OF A NOETHERIAN ALGEBRA [PDF]
Nagoya Mathematical Journal, 2016 We define canonical and $n$-canonical modules of a module-finite algebra over a Noether commutative ring and study their basic properties. Using $n$-canonical modules, we generalize a theorem on $(n,C)$-syzygy by Araya and Iima which generalize a well-known theorem on syzygies by Evans and Griffith.
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
The Canon(s) of Constitutional Law: An Introduction [PDF]
, 2000 Any discipline has a canon, a set of themes that organize the way in which people think about the discipline. Or, perhaps, any discipline has a number of competing canons. Is there a canon of constitutional law?
Tushnet, Mark V.
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Journal of Translational Medicine, 2020 Background Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptured IAs and trained machine ...
Kerry E. Poppenberg +13 more
doaj +1 more source