Results 41 to 50 of about 119,675 (311)

Canonical and Non-Canonical Roles of Connexin43 in Cardioprotection [PDF]

Biomolecules, 2020
Since the mid-20th century, ischemic heart disease has been the world’s leading cause of death. Developing effective clinical cardioprotection strategies would make a significant impact in improving both quality of life and longevity in the worldwide population.
Olga M. Rusiecka, Jade Montgomery, Sandrine Morel, Daniela Batista-Almeida, Raf Van Campenhout, Mathieu Vinken, Henrique Girao, Brenda R. Kwak   +7 more
openaire   +6 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Development of 3D-Stacked 1Megapixel Dual-Time-Gated SPAD Image Sensor with Simultaneous Dual Image Output Architecture for Efficient Sensor Fusion

Sensors
Sensor fusion is crucial in numerous imaging and sensing applications. Integrating data from multiple sensors with different field-of-view, resolution, and frame timing poses substantial computational overhead.
Kazuma Chida, Kazuhiro Morimoto, Naoki Isoda, Hiroshi Sekine, Tomoya Sasago, Yu Maehashi, Satoru Mikajiri, Kenzo Tojima, Mahito Shinohara, Ayman T. Abdelghafar, Hiroyuki Tsuchiya, Kazuma Inoue, Satoshi Omodani, Alice Ehara, Junji Iwata, Tetsuya Itano, Yasushi Matsuno, Katsuhito Sakurai, Takeshi Ichikawa   +18 more
doaj   +1 more source

Evaluation of interfacial strength of multilayer thin films polymer by nanoindentation technique

Mechanical Engineering Journal, 2019
Multilayer thin films polymer have been commonly used in a wide range of electronics applications, such as solar cells, photoconductors, semiconductors, and light-emitting diodes, in which failure due to delamination can occur.
Kenji INOUE, Farid TRIAWAN, Kazuaki INABA, Kikuo KISHIMOTO, Masashi NISHI, Michiyo SEKIYA, Kunihiko SEKIDO, Akihito SAITOH   +7 more
doaj   +1 more source

Canonical and Non-Canonical Notch Ligands [PDF]

, 2010
Notch signaling induced by canonical Notch ligands is critical for normal embryonic development and tissue homeostasis through the regulation of a variety of cell fate decisions and cellular processes. Activation of Notch signaling is normally tightly controlled by direct interactions with ligand-expressing cells, and dysregulated Notch signaling is ...
Brendan, D'Souza, Laurence, Meloty-Kapella, Gerry, Weinmaster   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Avicenna's concept of pain.

, 2010
Ibn Sina (Latin name - Avicenna, 980-1037) is a famous Muslim physician who wrote The Canon of Medicine. Pain-related writings within The Canon were identified and analysed and compared to Galen and Modern Pain Theory. We found evidence in The Canon that
Mark I. Johnson, Tashani, OA, Johnson, MI, Osama A. Tashani, MarkI. Johnson, OsamaA. Tashani   +5 more
core   +2 more sources