Results 41 to 50 of about 157,915 (300)

Computed Tomography Radiomic Signatures Associated With Neutrophil Extracellular Trap Enrichment and First‐Pass Outcome in Ischemic Stroke Thrombi

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Radiomic and transcriptomic analyses have independently identified features linked to mechanical thrombectomy (MT) outcomes. Here, we integrated paired radiomics/transcriptomics of stroke clots to identify neutrophil extracellular trap (NET ...
Briana A. Santo, Tatsat R. Patel, Seyyed M. Mousavi Janbeh Sarayi, Kerry E. Poppenberg, Sarah Balghonaim, Alexandria Scotti, TaJania D. Jenkins, Vinay Jaikumar, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Vincent M. Tutino   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Todo canon, el canon

Análisis Filosófico, 2010
En la consideración de numerosos asuntos y respecto de muy variadas exposiciones, el uso de expresiones como "filosófica" sugiere que debemos remitirnos a procederes, preguntas o exigencias especiales. Rabossi propone un modo de caracterizar el sentido con que usamos esas expresiones y, sobre esa base, concluye que la filosofía tal como se la practica ...
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Avicenna's concept of pain. [PDF]

, 2010
Ibn Sina (Latin name - Avicenna, 980-1037) is a famous Muslim physician who wrote The Canon of Medicine. Pain-related writings within The Canon were identified and analysed and compared to Galen and Modern Pain Theory. We found evidence in The Canon that
Mark I. Johnson, Tashani, OA, Johnson, MI, Osama A. Tashani, MarkI. Johnson, OsamaA. Tashani   +5 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Design thinking tools in creating business growth: Case Canon Oy, printing service for micro companies [PDF]

, 2020
Opinnäytetyön tavoitteena on tutkia muotoiluajattelua liiketoiminnan kasvun mahdollistajana. Eri kasvuteorioita on käsitelty muotoiluun yhdistettynä ja opinnäytetyön teoreettinen viitekehys muodostuukin näiden yhtymästä.
Lumenkoski, Hanna
core  

A plateau in the sensitivity of a compact optically pumped atomic magnetometer

AIP Advances, 2014
In a compact optically pumped atomic magnetometer (OPAM), there is a plateau in the sensitivity where the dependence of the sensitivity on pumping power is small compared with that predicted by the uniform polarization model. The mechanism that generates
Natsuhiko Mizutani, Kazuhisa Okano, Kazuhiro Ban, Sunao Ichihara, Akira Terao, Tetsuo Kobayashi   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source