Results 61 to 70 of about 119,675 (311)
The Clementines Dispendiosam and Saepe Contingit and the Evolution of the Medieval Summary Procedure
Journal on European History of Law, 2019 This article intends to explore briefly the steps that lead to the appearance of the summary Rite on the medieval Ius Commune, highlighting the role of Canon law, and in particular the legislative interventions of Pope Clement V, in the conformation of ...
Javier Belda Iniesta, Michela Coretti
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
unboxing the canon - Episode 5: Taken from the Headlines
, 2020 “Taken from the Headlines” considers European history painting, its roots and its legacies. What exactly are history paintings? And why are they significant in the canon of Western art? In this episode of “Unboxing the Canon” Dr.
Steer, Linda
core +1 more source
Canonical extensions and canonicity via dcpo presentations
Theoretical Computer Science, 2011 17 pages.
Gehrke, M., Vosmaer, J.
openaire +7 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
ON CANONICAL CONSTRUCTIONS. II [PDF]
Proceedings of the National Academy of Sciences, 1955 In the second paper in this series [2; 3], it was demonstrated that under suitable topological conditions on a space S (which are in particular always satisfied for a manifold), the problem of reconstructing S from its group G of homeomorphism onto itself may be reduced to the problem of reconstructing the points of S from G.
openaire +7 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Journal of Translational Medicine, 2020 Background Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptured IAs and trained machine ...
Kerry E. Poppenberg +13 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source