Results 61 to 70 of about 157,915 (300)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

ON CANONICAL CONSTRUCTIONS. II [PDF]

open access: yesProceedings of the National Academy of Sciences, 1955
In the second paper in this series [2; 3], it was demonstrated that under suitable topological conditions on a space S (which are in particular always satisfied for a manifold), the problem of reconstructing S from its group G of homeomorphism onto itself may be reduced to the problem of reconstructing the points of S from G.
openaire   +7 more sources

Canonical Typicality [PDF]

open access: yesPhysical Review Letters, 2006
It is well known that a system, S, weakly coupled to a heat bath, B, is described by the canonical ensemble when the composite, S+B, is described by the microcanonical ensemble corresponding to a suitable energy shell. This is true both for classical distributions on the phase space and for quantum density matrices.
GOLDSTEIN S   +3 more
openaire   +3 more sources

Fully automatic fossa ovalis segmentation from computed tomography images using deep neural network with atlas-based localization

open access: yesInformatics in Medicine Unlocked
Background and objective: Information on the location of the fossa ovalis (FO) is necessary for planning interventional procedures that require an inter-atrial septal (IAS) puncture.
Gakuto Aoyama   +7 more
doaj   +1 more source

The Clementines Dispendiosam and Saepe Contingit and the Evolution of the Medieval Summary Procedure

open access: yesJournal on European History of Law, 2019
This article intends to explore briefly the steps that lead to the appearance of the summary Rite on the medieval Ius Commune, highlighting the role of Canon law, and in particular the legislative interventions of Pope Clement V, in the conformation of ...
Javier Belda Iniesta, Michela Coretti
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Aproximación a un canon literario hispánico equitativo

open access: yes, 2023
As is well known, the Hispanic literary canon exhibits a certain androcentrism by obscuring not only works by female authors, but also the biographies of many writers who are essential to the cultural and historical heritage of our country.
Clavijo Corchero, Álvaro [0000-0002-9398-2052]
core   +1 more source

Classification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm

open access: yesJournal of Translational Medicine, 2020
Background Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptured IAs and trained machine ...
Kerry E. Poppenberg   +13 more
doaj   +1 more source

Home - About - Disclaimer - Privacy