Results 71 to 80 of about 157,915 (300)
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Loder, T.E. Canon. Canon T.E Loder interview, August 11, 1969.
, 1969 Canon Loder was rector of Parish of Grand Falls. He discusses coming to Grand Falls, serving a clergy to logging camps; history of Grand Falls and the pioneer citizens; and his life experiences as a clergyman in a growing, changing Newfoundland ...
Silk, Hiram
core
On doing what is just, right and fair
In die Skriflig, 2020 ‘Just’, ‘right’ and ‘fair’ are complex concepts without singular definitions. This article investigated these concepts from the perspective of Roman Catholic canon law. The historical and theological contexts of the Roman Catholic Church (the Church) are
Hildegard Warnink
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Canon Auto Zoom 518 Super 8 Camera
, 1964 Canon provides imaging, optical, and industrial products, such as lenses, cameras, scanners, medical equipment, printers, and semiconductor manufacturing equipment. In April 1964, Eastman Kodak announced a new 8mm film standard: Super 8.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2018 Relais Communiqué de Presse INRA - Vous trouverez ci-dessous le lien vers le Communiqué de Presse réalisé par l’INRA sur les recherches de Francis CANON, chercheur au Centre des Sciences du goût et de l’alimentation.
Canon, Francis
core +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source