Results 71 to 80 of about 490,920 (259)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Multivariate analysis applied to the study of the relationship between soil and plant properties in a peach orchard [PDF]

Revista Brasileira de Ciência do Solo, 2014
In the State of Rio Grande do Sul, the municipality of Pelotas is responsible for 90 % of peach production due to its suitable climate and soil conditions. However, there is the need for new studies that aim at improved fruit quality and increased yield.
Viviane Santos Silva Terra, Ricardo Alexandre Valgas, Carlos Reisser Júnior, Luis Carlos Timm, José Francisco Martins Pereira, Flávio Luiz Carpena Carvalho, Henrique Oldoni   +6 more
doaj  

Orthogonal polynomial kernels and canonical correlations for Dirichlet measures

, 2013
We consider a multivariate version of the so-called Lancaster problem of characterizing canonical correlation coefficients of symmetric bivariate distributions with identical marginals and orthogonal polynomial expansions.
Griffiths, Robert C., Spanò, Dario
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Exact correlation functions of the BCS model in the canonical ensemble

, 2002
We evaluate correlation functions of the BCS model for finite number of particles. The integrability of the Hamiltonian relates it with the Gaudin algebra ${\cal G}[sl(2)]$.
A. Di Lorenzo, A. Mastellone, Andreas Osterloh, C. T. Black, C. T. Black, C. T. Black, D. H. Rischke, E. K. Sklyanin, E. K. Sklyanin, F. A. Smirnov, F. Braun, F. Iachello, G. Sierra, G. Sierra, H. Heiselberg, J. Bardeen, J. von Delft, K. A. Matveev, L. Amico, Luigi Amico, M. C. Cambiaggio, M. Gaudin, M. Schechter, M. Tinkham, N. N. Bogoliubov, P. W. Anderson, R. W. Richardson, R. W. Richardson, R. W. Richardson, V. E. Korepin, V. E. Korepin   +30 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Genomic Prediction of Root Traits via Aerial Traits in Soybean Using Canonical Variables

International Journal of Plant Biology
The phenotypic evaluation of root traits in soybeans presents challenges in breeding due to its high cost and the requirement for experimental plot destruction. Establishing relationships between aerial and root traits is crucial, given the relative ease
Vitor Seiti Sagae, Noé Mitterhofer Eiterer Ponce de Leon da Costa, Matheus Massariol Suela, Dalton de Oliveira Ferreira, Ana Carolina Campana Nascimento, Camila Ferreira Azevedo, Felipe Lopes da Silva, Moysés Nascimento   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A note on the ordinal canonical correlation analysis of two sets of ranking scores [PDF]

In this paper we have proposed a method to conduct the ordinal canonical correlation analysis (OCCA) that yields ordinal canonical variates and the coefficient of correlation between them, which is analogous to (and a generalization of) the rank ...
Mishra, SK
core   +1 more source