Results 91 to 100 of about 1,105,140 (302)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

CCA: An R Package to Extend Canonical Correlation Analysis [PDF]

open access: yes
Canonical correlations analysis (CCA) is an exploratory statistical method to highlight correlations between two data sets acquired on the same experimental units.
Sébastien Déjean   +3 more
core  

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Canonical correlation analysis of the career attitudes and strategies inventory and the adult career concerns inventory

open access: yesSA Journal of Industrial Psychology, 2006
This study investigated the relationships between the scales of the Adult Career Concerns Inventory (ACCI) and those of the Career Attitudes and Strategies Inventory (CASI). The scores of 202 South African adults for the two inventories were subjected to
Charlene C Lew, Gideon P De Bruin
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

REPRESENTATION-CONSTRAINED CANONICAL CORRELATION-ANALYSIS: A HYBRIDIZATION OF CANONICAL CORRELATION AND PRINCIPAL COMPONENT ANALYSIS [PDF]

open access: yes
The classical canonical correlation analysis is extremely greedy to maximize the squared correlation between two sets of variables. As a result, if one of the variables in the dataset-1 is very highly correlated with another variable in the dataset-2 ...
Sudhanshu K MISHRA
core  

On Bivariate Distributions with Singular Part

open access: yesAxioms
There are many families of bivariate distributions with given marginals. Most families, such as the Farlie–Gumbel–Morgenstern (FGM) and the Ali–Mikhail–Haq (AMH), are absolutely continuous, with an ordinary probability density. In contrast, there are few
Carles M. Cuadras
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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