Results 11 to 20 of about 29,661 (112)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Integrable equations of the dispersionless Hirota type and hypersurfaces in the Lagrangian Grassmannian [PDF]

, 2007
We investigate integrable second order equations of the form F(u_{xx}, u_{xy}, u_{yy}, u_{xt}, u_{yt}, u_{tt})=0. Familiar examples include the Boyer-Finley equation, the potential form of the dispersionless Kadomtsev-Petviashvili equation, the ...
Ferapontov, E. V., Hadjikos, L., Khusnutdinova, K. R.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Survey on the Tukey theory of ultrafilters [PDF]

, 2014
This article surveys results regarding the Tukey theory of ultrafilters on countable base sets. The driving forces for this investigation are Isbell's Problem and the question of how closely related the Rudin-Keisler and Tukey reducibilities are.
Dobrinen, Natasha
core   +1 more source

Integrable (2+1)-dimensional systems of hydrodynamic type

, 2010
We describe the results that have so far been obtained in the classification problem for integrable (2+1)-dimensional systems of hydrodynamic type. The systems of Gibbons--Tsarev type are the most fundamental here.
A. C. Newell, A. V. Mikhailov, A. V. Mikhailov, A. V. Mikhailov, A. V. Odesskii, A. V. Odesskii, A. V. Odesskii, A. V. Odesskii, A. V. Odesskii, B. A. Dubrovin, B. A. Kupershmidt, D. J. Benney, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Zakharov, I. M. Gel’fand, I. M. Krichever, I. M. Krichever, J. Gibbons, K. Löwner, K. Takasaki, L. A. Takhtadzhyan, L. Martínez Alonso, M. Mañas, M. V. Pavlov, M. V. Pavlov, M. V. Pavlov, M. V. Pavlov, M. V. Saveliev, S. P. Tsarëv, S. P. Tsarëv, S. V. Manakov, S. V. Manakov, T. Takebe, V. E. Zakharov, V. E. Zakharov, V. P. Spiridonov, V. Shramchenko, V. V. Sokolov   +42 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Hamiltonian systems of hydrodynamic type in 2 + 1 dimensions

, 2007
We investigate multi-dimensional Hamiltonian systems associated with constant Poisson brackets of hydrodynamic type. A complete list of two- and three-component integrable Hamiltonians is obtained. All our examples possess dispersionless Lax pairs and an
A. Moro, B.A. Dubrovin, B.A. Dubrovin, C.P. Boyer, D.B. Fairlie, E. V. Ferapontov, E.V. Ferapontov, E.V. Ferapontov, E.V. Ferapontov, E.V. Ferapontov, I.M. Krichever, J. Gibbons, J. Gibbons, J. Haantjes, M. Blaszak, M. Blaszak, M. Burnat, M. Manas, M.V. Pavlov, O.I. Mokhov, S.K. Godunov, S.P. Tsarev, V. V. Sokolov, Z. Peradzyński   +23 more
core   +1 more source