Results 11 to 20 of about 29,917 (203)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Holonomy reductions of Cartan geometries and curved orbit decompositions

, 2014
We develop a holonomy reduction procedure for general Cartan geometries. We show that, given a reduction of holonomy, the underlying manifold naturally decomposes into a disjoint union of initial submanifolds.
Cap, Andreas, Gover, A. Rod, Hammerl, Matthias   +2 more
core   +1 more source

Integrable dispersionless PDE in 4D, their symmetry pseudogroups and deformations [PDF]

, 2015
We study integrable non-degenerate Monge-Ampere equations of Hirota type in 4D and demonstrate that their symmetry algebras have a distinguished graded structure, uniquely determining the equations.
Kruglikov, Boris, Morozov, Oleg
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Integrable equations of the dispersionless Hirota type and hypersurfaces in the Lagrangian Grassmannian [PDF]

, 2007
We investigate integrable second order equations of the form F(u_{xx}, u_{xy}, u_{yy}, u_{xt}, u_{yt}, u_{tt})=0. Familiar examples include the Boyer-Finley equation, the potential form of the dispersionless Kadomtsev-Petviashvili equation, the ...
Ferapontov, E. V., Hadjikos, L., Khusnutdinova, K. R.   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Survey on the Tukey theory of ultrafilters [PDF]

, 2014
This article surveys results regarding the Tukey theory of ultrafilters on countable base sets. The driving forces for this investigation are Isbell's Problem and the question of how closely related the Rudin-Keisler and Tukey reducibilities are.
Dobrinen, Natasha
core   +1 more source

Integrable (2+1)-dimensional systems of hydrodynamic type

, 2010
We describe the results that have so far been obtained in the classification problem for integrable (2+1)-dimensional systems of hydrodynamic type. The systems of Gibbons--Tsarev type are the most fundamental here.
A. C. Newell, A. V. Mikhailov, A. V. Mikhailov, A. V. Mikhailov, A. V. Odesskii, A. V. Odesskii, A. V. Odesskii, A. V. Odesskii, A. V. Odesskii, B. A. Dubrovin, B. A. Kupershmidt, D. J. Benney, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Ferapontov, E. V. Zakharov, I. M. Gel’fand, I. M. Krichever, I. M. Krichever, J. Gibbons, K. Löwner, K. Takasaki, L. A. Takhtadzhyan, L. Martínez Alonso, M. Mañas, M. V. Pavlov, M. V. Pavlov, M. V. Pavlov, M. V. Pavlov, M. V. Saveliev, S. P. Tsarëv, S. P. Tsarëv, S. V. Manakov, S. V. Manakov, T. Takebe, V. E. Zakharov, V. E. Zakharov, V. P. Spiridonov, V. Shramchenko, V. V. Sokolov   +42 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source