Results 21 to 30 of about 29,661 (112)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Group-invariant solutions of a nonlinear acoustics model

, 2015
Based on a recent classification of subalgebras of the symmetry algebra of the Zabolotskaya-Khokhlov equation, all similarity reductions of this equation into ordinary differential equations are obtained. Large classes of group-invariant solutions of the
Chowdhury A R, Enflo B O, Gibbons J Kodama Y, Güngör F, Güngör F, Hereman W, Ince E L, J C Ndogmo, Kuznetsov V P, Lie S, Ndogmo J C, Novikov B K, Olver P J, Polyanin A D, Ramani A, Schwarz F, Sindaoreji, Tamizhmani K M, Vinogradov A M, Webb G M, Winternitz P, Winternitz P, Zabolotskaya E A, Zhang J F   +23 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Topological Ramsey spaces from Fra\"iss\'e classes, Ramsey-classification theorems, and initial structures in the Tukey types of p-points [PDF]

, 2015
A general method for constructing a new class of topological Ramsey spaces is presented. Members of such spaces are infinite sequences of products of Fra\"iss\'e classes of finite relational structures satisfying the Ramsey property.
Dobrinen, Natasha, Mijares, Jose G., Trujillo, Timothy   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

The Maslov Gerbe

, 2003
Let Lag(E) be the grassmannian of lagrangian subspaces of a complex symplectic vector space E. We construct a Maslov class which generates the second integral cohomology of Lag(E), and we show that its mod 2 reduction is the characteristic class of a ...
Alan Weinstein, H. Omori, J. J. Duistermaat, J. L. Brylinski, L. Ho¨rmander, V. I. Arnol 'd   +5 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Exact nonclassical symmetry solutions of Arrhenius reaction-diffusion

, 2015
Exact solutions for nonlinear Arrhenius reaction-diffusion are constructed in $n$ dimensions. A single relationship between nonlinear diffusivity and the nonlinear reaction term leads to a nonclassical Lie symmetry whose invariant solutions have a heat ...
Bradshaw-Hajek, B. H., Broadbridge, P., Triadis, D.   +2 more
core   +1 more source