Results 161 to 170 of about 396,548 (332)
Supplementary Figure 6 from A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice [PDF]
, 2023 Jo Waaler +13 more
openalex +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway [PDF]
, 2017 Junming Huang +7 more
openalex +1 more source
Advanced Science, EarlyView.NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu +9 more
wiley +1 more source
Genome‐wide analysis of canonical Wnt target gene regulation in Xenopus tropicalis challenges β‐catenin paradigm [PDF]
, 2017 Yukio Nakamura, Stefan Hoppler
openalex +1 more source
Advanced Science, EarlyView.In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao +6 more
wiley +1 more source
p63 and canonical Wnt signaling [PDF]
Cell Cycle, 2010 Flaminia Talos, Ramona Schulz, Ute Moll
openaire +1 more source
Advanced Science, EarlyView.Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang +27 more
wiley +1 more source
Supplementary Figure 1 from Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis
, 2023 Yaqing Zhang +9 more
openalex +1 more source