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Cell Biology of Canonical Wnt Signaling. [PDF]
Annual Review of Cell and Developmental Biology, 2021 Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin stabilization. We review recent investigations that uncover new cell physiological effects through the regulation of Wnt receptor endocytosis, Wnt-induced stabilization ...
L. Albrecht +2 more
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Canonical Wnt Pathway and Glioma
Advances in Clinical Medicine, 2023 瑜 苏
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Canonical WNT signaling during kidney development
American Journal of Physiology-Renal Physiology, 2007The canonical WNT signaling pathway plays a crucial role in patterning of the embryo during development, but little is known about the specific developmental events which are under WNT control. To understand more about how the WNT pathway orchestrates mammalian organogenesis, we studied the canonical β-catenin-mediated WNT signaling pathway in kidneys ...
Diana M, Iglesias +9 more
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p120-catenin in canonical Wnt signaling
Critical Reviews in Biochemistry and Molecular Biology, 2017Canonical Wnt signaling controls β-catenin protein stabilization, its translocation to the nucleus and the activation of β-catenin/Tcf-4-dependent transcription. In this review, we revise and discuss the recent results describing actions of p120-catenin in different phases of this pathway. More specifically, we comment its involvement in four different
Mireia, Duñach +2 more
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A Wnt canon orchestrating osteoblastogenesis
Trends in Cell Biology, 2006Several transcription factors have been identified that control the differentiation of osteoblasts; however, relatively little is known about the signaling pathways involved in regulating the differentiation process. Recently, the canonical Wnt-beta-catenin pathway has been implicated in osteoblastogenesis.
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Aberrant canonical Wnt signaling: Phytochemical based modulation
Phytomedicine, 2020Wnt signaling pathway plays a major role during development like gastrulation, axis formation, organ development and organization of body plan development. Wnt signaling aberration has been linked with various disease conditions like osteoporosis, colon cancer, hair follicle tumor, Leukemia, and Alzheimer's disease.
Suman Manandhar +2 more
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The Canonical Wnt Signaling Pathway in Autism
CNS & Neurological Disorders - Drug Targets, 2014Mounting attention is being focused on the canonical Wnt signaling pathway which has been implicated in the pathogenesis of autism in some our and other recent studies. The canonical Wnt pathway is involved in cell proliferation, differentiation and migration, especially during nervous system development. Given its various functions, dysfunction of the
Yinghua, Zhang +3 more
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