Results 61 to 70 of about 71,269 (263)

ZNF9 activates cap independent-translation of the human ODC mRNA.

, 2013
A. Diagram of the ODC bicistronic vector for measuring cap-independent translation of human ODC. 5′meG: 5′-methyl-G cap structure. B. HeLa cells expressing the ODC bicistronic vector and either V5-ZNF9 or V5-LacZ were analyzed for luciferase activity ...
Morgan A. Sammons (366974), Bjarne Udd (366976), Amanda K. Antons (52433), Andrew J. Link (366977), Ralf Krahe (26237), Mourad Bendjennat (366975)   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Leishmania RNA Virus 1-Mediated Cap-Independent Translation [PDF]

Molecular and Cellular Biology, 1995
Recently, a group of related Leishmania RNA viruses (Leishmania RNA virus 1 [LRV1]) has been isolated from Leishmania guyanensis and L. brasiliensis. These viruses persist in the cytoplasm and contain double-stranded RNA genomes. Miniexon sequences are absent from the 5' end of the viral RNA, and the 5' end of the viral RNA lacks a cap structure ...
J A, Maga, G, Widmer, J H, LeBowitz
openaire   +2 more sources

Cap-independent translation of ODC is defective in DM2 myoblasts.

, 2013
A. IRES activity in wild-type and DM2 myoblast. Equal numbers of human wild-type or DM2 myoblasts were infected with virions expressing the bicistronic ODC reporter vector and were analyzed for luciferase activity.
Morgan A. Sammons (366974), Bjarne Udd (366976), Amanda K. Antons (52433), Andrew J. Link (366977), Ralf Krahe (26237), Mourad Bendjennat (366975)   +5 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Context-influenced cap-independent translation of Tombusvirus mRNAs in vitro

Virology, 2008
Tomato bushy stunt virus (TBSV) possesses a positive-strand RNA genome that is not 5'-capped or 3'-polyadenylated. Previous analysis revealed that the TBSV genome contains a 3'-cap-independent translational enhancer (3'CITE) in its 3'-untranslated region (3'UTR) that facilitates translation of viral mRNAs in vivo. A long-range 5'-3' RNA-RNA interaction
Nicholson, Beth L., White, K. Andrew
openaire   +2 more sources

Cap-independent enhancement of translation by a plant potyvirus 5' nontranslated region [PDF]

Journal of Virology, 1990
The RNA genome of tobacco etch virus (TEV), a plant potyvirus, functions as an mRNA for synthesis of a 346-kilodalton polyprotein that undergoes extensive proteolytic processing. The RNA lacks a normal 5' cap structure at its terminus, which suggests that the mechanism of translational initiation differs from that of a normal cellular mRNA.
J C, Carrington, D D, Freed
openaire   +2 more sources

The involvement of cap-independent mRNA translation in cell fate\r\ndecisions

, 2023
During cell stress many biochemical processes are shut down. For\r\nexample, global mRNA translation initiation is inhibited due to the\r\ndisruption of the cap-dependent mRNA recruitment mechanism.
Morrison, J. Kaitlin, NC DOCKS at East Carolina University   +1 more
core