Results 41 to 50 of about 71,269 (263)
Pervasive translation of circular RNAs driven by short IRES-like elements
Nature Communications, 2022 Unbiased screen of random sequences identified many short IRES-like elements to drive circular RNA translation and hundreds of rolling circle translation events, suggesting a pervasive cap-independent translation in human transcriptome.
Xiaojuan Fan +3 more
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Localized IRES-dependent translation of ER chaperone protein mRNA in sensory axons. [PDF]
PLoS ONE, 2012 Transport of neuronal mRNAs into distal nerve terminals and growth cones allows axonal processes to generate proteins autonomous from the cell body.
Almudena Pacheco, Jeffery L Twiss
doaj +1 more source
Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas
Molecular Cancer, 2022 Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a 5’ end cap and a 3’ end poly (A) tail necessary for cap-dependent translation.
Yan Wang +9 more
doaj +1 more source
Cell Reports, 2017 Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms.
Deepika Vasudevan +6 more
doaj +1 more source
mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription
Cell Reports, 2018 Summary: mRNA cap addition occurs early during RNA Pol II-dependent transcription, facilitating pre-mRNA processing and translation. We report that the mammalian mRNA cap methyltransferase, RNMT-RAM, promotes RNA Pol II transcription independent of mRNA ...
Dhaval Varshney +5 more
doaj +1 more source
5' cap-independent translation of dengue virus genomic RNA
Revista Peruana de Medicina Experimental y Salud Pública, 2015 Objetives. To analyze the involvement of methyl guanosine triphosphate cap (5’cap) and the start site of the genomic RNA of Dengue virus serotype 2 (DENV-2) American genotype in translation, using a cell-free system prepared from human placenta ...
Mariela Pérez Dominguez +5 more
doaj +1 more source
The insulin receptor cellular IRES confers resistance to eIF4A inhibition
eLife, 2013 Under conditions of stress, such as limited growth factor signaling, translation is inhibited by the action of 4E-BP and PDCD4. These proteins, through inhibition of eIF4E and eIF4A, respectively, impair cap-dependent translation. Under stress conditions
Calla M Olson +3 more
doaj +1 more source
The Triticum Mosaic Virus 5' Leader Binds to Both eIF4G and eIFiso4G for Translation. [PDF]
PLoS ONE, 2017 We recently identified a remarkably strong (739 nt-long) IRES-like element in the 5' untranslated region (UTR) of Triticum mosaic virus (TriMV, Potyviridae).
Robyn Roberts +3 more
doaj +1 more source
trans Regulation of Cap-Independent Translation by a Viral Subgenomic RNA [PDF]
Journal of Virology, 2006 ABSTRACT Many positive-strand RNA viruses generate 3′-coterminal subgenomic mRNAs to allow translation of 5′-distal open reading frames. It is unclear how viral genomic and subgenomic mRNAs compete with each other for the cellular translation machinery.
Shen, Ruizhong +2 more
openaire +3 more sources
Role for poliovirus protease 2A in cap independent translation. [PDF]
The EMBO Journal, 1994 Viral protein synthesis in poliovirus infected cells was found to be influenced by mutations in part of the viral 5'-non-coding region (NCR) in a temperature dependent manner. At elevated temperatures these mutations resulted in virus titre reductions that allowed selection of revertant viruses.
A J, Macadam +5 more
openaire +2 more sources