Results 31 to 40 of about 71,269 (263)
Exploring the Role of AUG Triplets in Human Cap-Independent Translation Enhancing Elements. [PDF]
Biochemistry, 2018 Cap-independent translation is believed to play an important role in eukaryotic protein synthesis, but the mechanisms of ribosomal recruitment and translation initiation remain largely unknown.
Juba AN, Chaput JC, Wellensiek BP.
europepmc +2 more sources
Regulation of cellular anabolism by mTOR: or how I learned to stop worrying and love translation
Sports Medicine and Health Science, 2020 The process and regulation of cellular metabolism are extremely complex and accomplished through multiple signalling pathways that operate in parallel, and often experience significant overlap in upstream and downstream a signal transduction.
J. William Deaver +5 more
doaj +1 more source
Reversal of G-Quadruplexes’ Role in Translation Control When Present in the Context of an IRES
Biomolecules, 2022 G-quadruplexes (GQs) are secondary nucleic acid structures that play regulatory roles in various cellular processes. G-quadruplex-forming sequences present within the 5′ UTR of mRNAs can function not only as repressors of translation but also as elements
Mohammed Enamul Hoque +2 more
doaj +1 more source
Cap-independent translation of plant viral RNAs [PDF]
Virus Research, 2006 The RNAs of many plant viruses lack a 5' cap and must be translated by a cap-independent mechanism. Here, we discuss the remarkably diverse cap-independent translation elements that have been identified in members of the Potyviridae, Luteoviridae, and Tombusviridae families, and genus Tobamovirus.
Elizabeth L Pettit, Kneller +2 more
openaire +2 more sources
Cap‐independent translation of maize Hsp101 [PDF]
The Plant Journal, 2005 SummaryMaize embryonic axes contain stored mRNAs, some of which are able to undergo cap‐independent translation initiation during germination. The Hsp101 mRNA, encoding a heat shock protein, is essential for thermo‐tolerance induction and is present among the stored transcripts.
Tzvetanka D, Dinkova +5 more
openaire +2 more sources
Cis-Acting Sequence Elements and Upstream Open Reading Frame in Mouse Utrophin-A 5'-UTR Repress Cap-Dependent Translation. [PDF]
PLoS ONE, 2015 Utrophin, the autosomal homologue of dystrophin can functionally compensate for dystrophin deficiency. Utrophin upregulation could therefore be a therapeutic strategy in Duchenne Muscular Dystrophy (DMD) that arises from mutation in dystrophin gene.
Trinath Ghosh, Utpal Basu
doaj +1 more source
Cap-independent translation initiation in Xenopus oocytes [PDF]
Nucleic Acids Research, 1997 Eukaryotic cellular mRNAs contain a cap at their 5'-ends, but some viral and cellular mRNAs bypass the cap-dependent mechanism of translation initiation in favor of internal entry of ribosomes at specific RNA sequences. Cap-dependent initiation requires intact initiation factor eIF4G (formerly eIF-4gamma, eIF-4Fgamma or p220), whereas internal ...
B D, Keiper, R E, Rhoads
openaire +2 more sources
Cap-independent translation through the p27 5'-UTR [PDF]
Nucleic Acids Research, 2007 Several recent publications have explored cap-independent translation through an internal ribosome entry site (IRES) in the 5'-UTR of the mRNA encoding the cyclin-dependent kinase inhibitor p27. The major experimental tool used in these reports was the use of bicistronic reporter constructs in which the 5'-UTR was inserted between the upstream and ...
Jiang, Hong +4 more
openaire +2 more sources
Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
eLife, 2021 During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5’UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation.
Fatima Alghoul +3 more
doaj +1 more source
Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. [PDF]
, 2006 The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5' end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5'-terminal m(7)Gppp cap of the mRNA,
von der Haar, Tobias +8 more
core +1 more source