Investigation of cap-independent translation in neuronal differentiation [PDF]
, 2020 Initiation der Translation ist ein komplexer und stark regulierter Prozess, bei dem Ribosomen die mRNA binden. Die überwiegende Mehrheit eukaryotischer mRNAs wird durch einen 5‘-Cap-abhängigen Mechanismus translatiert. Dazu bindet der eIF4F-Proteinkomplex die mRNA an der 5'-Cap-Struktur, um weitere eIFs und die kleine ribosomale Untereinheit zu ...
Ruhe, Larissa
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IRES-mediated cap-independent translation, a path leading to hidden proteome. [PDF]
J Mol Cell Biol, 2019 AbstractMost eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) can serve as an alternative mechanism for protein production. Many IRESs have been discovered from viral or cellular mRNAs to promote ribosome assembly and initiate ...
Yang Y, Wang Z.
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PABP/purine-rich motif as an initiation module for cap-independent translation in pattern-triggered immunity [PDF]
Cell, 2022 Guoyong Xu, Xinnian Dong
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Protein synthesis in eukaryotes: The growing biological relevance of cap-independent translation initiation [PDF]
Biological Research, 2005 Ribosome recruitment to eukaryotic mRNAs is generally thought to occur by a scanning mechanism, whereby the 40S ribosomal subunit binds in the vicinity of the 5'cap structure of the mRNA and scans until an AUG codon is encountered in an appropriate ...
MARCELO LÓPEZ-LASTRA +2 more
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The Warburg Effect: A Possible Role Of Cap Independent Translation [PDF]
, 2017 Cancer is a complex multistep process involving tremendous changes at molecular and cellular properties of a cancerous cell. One of the main characteristics associated with the tumor cells include preferential use of glycolysis over oxidative phosphorylation to meet the high energy needs. This process is observed even in the presence of ample oxygen to
Ajaz Ahmad Waza* , Shabir Ahmad Bhat, Sajad Ali
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Mechanistic differences in eukaryotic initiation factor requirements for eIF4GI-driven cap-independent translation of structured mRNAs [PDF]
Journal of Biological ChemistryDixie J Goss, Solomon A Haizel
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Cap-independent translation: A shared mechanism for lifespan extension by rapamycin, acarbose, and 17α-estradiol. [PDF]
Aging Cell, 2021 We hypothesized that rapamycin (Rapa), acarbose (ACA), which both increase mouse lifespan, and 17α‐estradiol, which increases lifespan in males (17aE2) all share common intracellular signaling pathways with long‐lived Snell dwarf, PAPPA‐KO, and Ghr ...
Shen Z, Hinson A, Miller RA, Garcia GG.
europepmc +2 more sources
Cap-independent translation directs stress-induced differentiation of the protozoan parasite Toxoplasma gondii. [PDF]
J Biol ChemTranslational control mechanisms modulate the microbial latency of eukaryotic pathogens, enabling them to evade immunity and drug treatments. The protozoan parasite Toxoplasma gondii persists in hosts by differentiating from proliferative tachyzoites to ...
Dey V +4 more
europepmc +2 more sources
Translation of Plant RNA Viruses
Viruses, 2021 Plant RNA viruses encode essential viral proteins that depend on the host translation machinery for their expression. However, genomic RNAs of most plant RNA viruses lack the classical characteristics of eukaryotic cellular mRNAs, such as mono-cistron, 5′
Guowei Geng +7 more
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RNA-Protein Interactome at the Hepatitis E Virus Internal Ribosome Entry Site
Microbiology Spectrum, 2023 Multiple processes exist in a cell to ensure continuous production of essential proteins either through cap-dependent or cap-independent translation processes. Viruses depend on the host translation machinery for viral protein synthesis.
Shiv Kumar +11 more
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