Enhancing cap-independent translation of linear mRNA [PDF]
Nature CommunicationsWhile cap-dependent translation remains the primary focus in mRNA-based therapeutics, cap-independent translation holds promise for targeting diseases ranging from cancer to neurodegeneration.
Sebastian Golojuch +3 more
doaj +8 more sources
Cap-independent translation in Haematological Malignancies [PDF]
Frontiers in Oncology, 2015 Haematological malignancies are a heterogeneous group of diseases deriving from blood cells progenitors. Although many genes involved in blood cancers contain Internal Ribosome Entry Sites (IRESes) there has been only few studies focusing on the role of ...
Emilie eHorvilleur +5 more
doaj +7 more sources
Cap-Independent Circular mRNA Translation Efficiency
Vaccines, 2023 Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less
Andrei A. Deviatkin +9 more
doaj +6 more sources
Human cytomegalovirus pTRS1 stimulates cap-independent translation [PDF]
Virology, 2019 Human cytomegalovirus (HCMV) manipulates multiple cellular processes to facilitate virus replication, including the control of mRNA translation. We previously showed that the HCMV TRS1 protein (pTRS1) promotes cap-dependent mRNA translation independent of its ability to antagonize the antiviral protein PKR.
Heather A Vincent +2 more
exaly +6 more sources
5′ UTR m6A Promotes Cap-Independent Translation [PDF]
Cell, 2015 Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a cap-independent manner through poorly understood mechanisms. Here, we show that mRNAs containing N(6)-methyladenosine (m(6)A) in their 5' UTR can be translated in a cap ...
Kate D Meyer +2 more
exaly +6 more sources
The 3′ Untranslated Region of a Plant Viral RNA Directs Efficient Cap-Independent Translation in Plant and Mammalian Systems [PDF]
Pathogens, 2019 Many plant viral RNA genomes lack a 5′ cap, and instead are translated via a cap-independent translation element (CITE) in the 3′ untranslated region (UTR).
Jelena J. Kraft +8 more
doaj +6 more sources
Structural and Functional Diversity of Plant Virus 3′-Cap-Independent Translation Enhancers (3′-CITEs) [PDF]
Frontiers in Plant Science, 2017 Most of the positive-strand RNA plant viruses lack the 5′-cap and/or the poly(A)-tail that act synergistically to stimulate canonical translation of cellular mRNAs.
Verónica Truniger +2 more
doaj +5 more sources
Stabilization of the G-quadruplex at the VEGF IRES represses cap-independent translation [PDF]
RNA Biology, 2015 The activation of translation contributes to malignant transformation and is an emerging target for cancer therapies. RNA G-quadruplex structures are general inhibitors of cap-dependent mRNA translation and were recently shown to be targeted for oncoprotein translational activation.
Anne Cammas +2 more
exaly +6 more sources
Crystal structure of a cap-independent translation enhancer RNA. [PDF]
Nucleic Acids Res, 2023 Abstract In eukaryotic messenger RNAs, the 5′ cap structure binds to the translation initiation factor 4E to facilitate early stages of translation. Although many plant viruses lack the 5′ cap structure, some contain cap-independent translation elements (CITEs) in their 3′ untranslated region.
Lewicka A +5 more
europepmc +6 more sources
Circular RNAs’ cap-independent translation protein and its roles in carcinomas [PDF]
Molecular Cancer, 2021 Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood.
Lian He +5 more
doaj +4 more sources