Results 71 to 80 of about 3,906,604 (254)
Aquaculture ReportsThe present study aimed to comparatively evaluate the protein requirements of large yellow croaker (initial body weight: 17.03 ± 0.11 g) fed with five dietary protein sources including fish meal (FM), cottonseed protein concentrate (CPC), Clostridium ...
Yingxu Huangfu +8 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
BMI1, stem cell factor acting as novel serum-biomarker for Caucasian and African-American prostate cancer. [PDF]
PLoS ONE, 2013 Lack of reliable predictive biomarkers is a stumbling block in the management of prostate cancer (CaP). Prostate-specific antigen (PSA) widely used in clinics has several caveats as a CaP biomarker.
Hifzur Rahman Siddique +8 more
doaj +1 more source
A capping domain for LRR protein interaction modules [PDF]
FEBS Letters, 1999 Leucine‐rich repeats (LRR) are protein interaction modules which are present in a large number of proteins with diverse functions. We describe here a novel motif (16–19 residues) downstream of the last, incomplete, LRR in a subfamily of LRR proteins. In the U2A’ spliceosomal protein, this motif is folded into a cap that shields the hydrophobic core of ...
Ceulemans, Hugo +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathogens, 2017 Cap-snatching was first discovered in influenza virus. Structures of the involved domains of the influenza virus polymerase, namely the endonuclease in the PA subunit and the cap-binding domain in the PB2 subunit, have been solved.
Maria Rosenthal +7 more
doaj +1 more source
A script to highlight hydrophobicity and charge on protein surfaces [PDF]
, 2015 The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo +12 more
core +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
A major agonist-regulated capping activity in Dictyostelium is due to the capping protein, cap32/34
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1996 Stimulation of starved Dictyostelium amoebae with the chemoattractant cAMP produces a rapid increase in actin nucleation activity at 5 seconds which is cotemporal with an increase in actin assembly and a decrease in Ca(2+)-insensitive capping activity [1].
Eddy, Robert J +3 more
openaire +2 more sources