Results 1 to 10 of about 3,771,869 (289)
iScience, 2021 Summary: Lasso-grafting (LG) technology is a method for generating de novo biologics (neobiologics) by genetically implanting macrocyclic peptide pharmacophores, which are selected in vitro against a protein of interest, into loops of arbitrary protein ...
Yamato Komatsu +8 more
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Molecules, 2023 Hepatitis E virus (HEV) is the notable causative agent of acute and chronic hepatic, renal, pancreatic, neurological, and hematopoietic blood cell infections with high risk in immunocompromised patients. Hepatic failure is mostly documented among adults,
Ghulam Mustafa +6 more
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hepatitis c Virus p7 is critical for capsid assembly and envelopment.
PLoS Pathogens, 2013 Hepatitis C virus (HCV) p7 is a membrane-associated ion channel protein crucial for virus production. To analyze how p7 contributes to this process, we dissected HCV morphogenesis into sub-steps including recruitment of HCV core to lipid droplets (LD ...
Juliane Gentzsch +9 more
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Structural roles of PCV2 capsid protein N-terminus in PCV2 particle assembly and identification of PCV2 type-specific neutralizing epitope. [PDF]
PLoS Pathogens, 2019 Postweaning multisystemic wasting disease (PMWS) in piglets caused by porcine circovirus type 2 (PCV2) is one of the major threats to most pig farms worldwide.
Xiaobing Mo +5 more
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Venezuelan Equine Encephalitis Virus Capsid—The Clever Caper
Viruses, 2017 Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus that is vectored by mosquitos and cycled in rodents. It can cause disease in equines and humans characterized by a febrile illness that may progress into encephalitis.
Lindsay Lundberg +2 more
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Structure and Antigenicity of the Porcine Astrovirus 4 Capsid Spike
VirusesPorcine astrovirus 4 (PoAstV4) has been recently associated with respiratory disease in pigs. In order to understand the scope of PoAstV4 infections and to support the development of a vaccine to combat PoAstV4 disease in pigs, we designed and produced a
Danielle J. Haley +6 more
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Multi-Enzyme Assembly on T4 Phage Scaffold
Frontiers in Bioengineering and Biotechnology, 2020 Over the past two decades, various scaffolds have been designed and synthesized to organize enzyme cascades spatially for enhanced enzyme activity based on the concepts of substrate channeling and enhanced stability.
Jinny L. Liu +4 more
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The role of chikungunya virus capsid-viral RNA interactions in programmed ribosomal frameshifting
Journal of VirologyChikungunya virus (CHIKV) is a globally significant arthropod-borne virus that causes outbreaks in tropical and subtropical regions and is rapidly expanding in geographical range.
Jordan A. Farrington +2 more
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Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro
Bio-Protocol, 2019 The stability of the HIV-1 capsid and the spatiotemporal control of its disassembly, a process called uncoating, need to be finely tuned for infection to proceed.
Chantal Márquez +6 more
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The 4.4 Å Capsid Structure of the Giant Melbournevirus Belonging to the Marseilleviridae Family
VirusesMembers of Marseilleviridae, a family of icosahedral giant viruses, have been identified worldwide in all types of environments. The virion shows a characteristic internal membrane extrusion at the five-fold vertices of the capsid, but its structural ...
Raymond N. Burton-Smith +3 more
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