Results 1 to 10 of about 166,210 (263)

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly

mBio, 2022
Morphogenesis of herpesvirus particles is highly conserved; however, the capsid assembly and genome packaging of human cytomegalovirus (HCMV) exhibit unique features.
Eva Maria Borst, Sarah Harmening, Saskia Sanders, Enrico Caragliano, Karen Wagner, Tihana Lenac Roviš, Stipan Jonjić, Jens Bernhard Bosse, Martin Messerle   +8 more
doaj   +7 more sources

Arthritogenic Alphavirus Capsid Protein

Life, 2021
In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Shambhavi Rao, Adam Taylor
doaj   +4 more sources

The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling

Viruses, 2021
Alphaviruses are arthropod-borne RNA viruses which can cause either mild to severe febrile arthritis which may persist for months, or encephalitis which can lead to death or lifelong cognitive impairments.
V. Douglas Landers, Daniel W. Wilkey, Michael L. Merchant, Thomas C. Mitchell, Kevin J. Sokoloski   +4 more
doaj   +1 more source

Stimulation of dendritic cell functional maturation by capsid protein from chikungunya virus [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Chikungunya virus (ChikV) infection is characterized by persistent infection in joints and lymphoid organs. The ChikV Capsid protein plays an important role in regulating virus replication. In this study, we hypothesized that capsid protein
Vu Nghia, Nguyen Giang, Nguyen Canh, Nguyen Ha, Nguyen Duong, Nguyen Huy Hoang, Nguyen Xuan   +6 more
doaj   +1 more source

Robust Deep Neural Network-Based Framework for Predicting and Classifying Capsid Protein Based on Biomedical Data

IEEE Access, 2023
Capsid protein is a pathogenic protein that needs to be examined because it helps in the virus’s proliferation and mutation. Due to this protein, the virus can replicate and reproduce itself.
Anees Ur Rahman Khattak, Amin Ullah, Amjad Rehman, Tariq Mahmood, Qamar Wahid Khattak, Sarah Alotaibi, Saeed Ali Omer Bahaj   +6 more
doaj   +1 more source

Large-scale functional purification of recombinant HIV-1 capsid. [PDF]

PLoS ONE, 2013
During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the viral nucleoprotein complexes.
Magdeleine Hung, Anita Niedziela-Majka, Debi Jin, Melanie Wong, Stephanie Leavitt, Katherine M Brendza, Xiaohong Liu, Roman Sakowicz   +7 more
doaj   +1 more source

Evaluation of a Virus-like Nanoparticle Porcine Circovirus Type-2 (PCV2) Capsid Protein Fused with the Pig Immunoglobulin Fc Fragment as a Novel Vaccine Candidate against PCV2 in Mice

Vaccines, 2021
Porcine circovirus Type 2 (PCV2) is a primary etiological pathogen of post-weaning multi-systemic wasting syndrome (PMWS). The capsid protein of PCV2 is the crucial immunogenic protein which can induce antibody generation and immune responses.
Qingping Luo, Waqas Ahmed, Yichen Dai, Ali Mohsin, Haifeng Hang, Yingping Zhuang, Meijin Guo   +6 more
doaj   +1 more source

High repetitive arginine in the anterior of PCV3 capsid protein is a severe obstacle for its expression in E. coli

AMB Express, 2020
Porcine circovirus type 3 (PCV3) is a novel circovirus identified in sows with PDNS-like clinical signs and reproductive failure. The capsid protein (CAP) of PCV3 is expected to be an effective vaccine candidate.
Bing Yan Liu, Bin Gao, Meng Zhi Liu, Ting Ting Zhang, Bao Shan Liu, Ze Liang Chen   +5 more
doaj   +1 more source

The Monoclonal Antibody Recognized the Open Reading Frame Protein in Porcine Circovirus Type 2-Infected Peripheral Blood Mononuclear Cells

Viruses, 2020
The purpose of this study in the context of the open reading frame 3 (ORF3) protein of porcine circovirus type 2 (PCV2) was especially its location and its relation to the capsid protein and the apoptosis protein in PCV2-infected porcine peripheral blood
Ling-Chu Hung
doaj   +1 more source

Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants. [PDF]

PLoS Pathogens, 2017
Alphaviruses are arthropod-borne viruses that represent a significant threat to public health at a global level. While the formation of alphaviral nucleocapsid cores, consisting of cargo nucleic acid and the viral capsid protein, is an essential ...
Kevin J Sokoloski, Lauren M Nease, Nicholas A May, Natasha N Gebhart, Claire E Jones, Thomas E Morrison, Richard W Hardy   +6 more
doaj   +1 more source