Results 31 to 40 of about 166,210 (263)
PLoS Pathogens, 2020 Protein phosphorylation plays an important role during the life cycle of many viruses. Venezuelan equine encephalitis virus (VEEV) capsid protein has recently been shown to be phosphorylated at four residues.
Brian D Carey +9 more
doaj +1 more source
Cell Reports, 2019 Summary: Myxovirus resistance 2 (MX2/MXB) is an interferon (IFN)-induced HIV-1 restriction factor that inhibits viral nuclear DNA accumulation. The amino-terminal domain of MX2 binds the viral capsid and is essential for inhibition.
Gilberto Betancor +5 more
doaj +1 more source
The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly [PDF]
The FEBS Journal, 2009 The mature capsid of human immunodeficiency virus, HIV‐1, is formed by the assembly of copies of a capsid protein (CA). The C‐terminal domain of CA, CTD, is able to homodimerize and most of the dimerization interface is formed by a single α‐helix from each monomer.
openaire +2 more sources
Diagnostic Potential of Parechovirus Capsid Proteins [PDF]
Journal of Clinical Microbiology, 2003 ABSTRACT To study humoral and cellular immunity against human parechovirus type 1 (HPEV1), the viral capsid proteins VP0, VP1, and VP3 were expressed and purified as glutathione S -transferase (GST)-tagged recombinant proteins. The fusion proteins were used to raise antisera in rabbits.
Annu, Alho +3 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Structures of Three Actinobacteriophage Capsids: Roles of Symmetry and Accessory Proteins
Viruses, 2020 Here, we describe the structure of three actinobacteriophage capsids that infect Mycobacterium smegmatis. The capsid structures were resolved to approximately six angstroms, which allowed confirmation that each bacteriophage uses the HK97-fold to form ...
Jennifer Podgorski +6 more
doaj +1 more source
Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein.
PLoS Pathogens, 2023 Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the ...
Lauri Ilmari Aurelius Pulkkinen +8 more
doaj +1 more source
Journal of General Virology, 2005 The rotavirus capsid is made up of three concentric protein layers. The outer layer, consisting of VP7 and VP4, is lost during virus entry into the host cell. Rotavirus field isolates can be adapted to high-titre growth in tissue culture by treatment with trypsin and by supplementing the culture medium with trypsin, which cleaves VP4 into two fragments,
Benureau, Yann +4 more
openaire +4 more sources
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source