Results 21 to 30 of about 166,210 (263)
The Enigmatic Capsid Protein of an Encephalitic Rubivirus [PDF]
Journal of Virology, 2021 The genus Rubivirus was previously comprised of a single member, Rubella virus (RuV), which is spread by airborne or maternal-fetal transmission and only infects humans (1).….
Pratyush Kumar Das, Margaret Kielian
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The Astrovirus Capsid: A Review
Viruses, 2017 Astroviruses are enterically transmitted viruses that cause infections in mammalian and avian species. Astroviruses are nonenveloped, icosahedral viruses comprised of a capsid protein shell and a positive-sense, single-stranded RNA genome.
Carlos F. Arias, Rebecca M. DuBois
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Frontiers in Microbiology, 2022 In the past decade, dengue virus infection is one of the most prevalent and rapidly spreading arthropod-borne diseases worldwide with about 400 million infections every year.
Yaoxing Wu +7 more
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Proton-Linked Dimerization of a Retroviral Capsid Protein Initiates Capsid Assembly [PDF]
Structure, 2009 In mature retroviral particles, the capsid protein (CA) forms a shell encasing the viral replication complex. Human immunodeficiency virus (HIV) CA dimerizes in solution, through its C-terminal domain (CTD), and this interaction is important for capsid assembly.
Bailey, Graham +3 more
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Capsid-Incorporation of Antigens into Adenovirus Capsid Proteins for a Vaccine Approach [PDF]
Molecular Pharmaceutics, 2010 Some viral vectors are potent inducers of cellular and humoral responses; therefore, viral vectors can be used to vaccinate against cancer or infectious diseases. This report will focus on adenovirus (Ad)-based vectors. Traditional viral-vector vaccination embodies the concept that the vector uses the host-cell machinery to express antigens that are ...
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Heat induced capsid disassembly and DNA release of bacteriophage λ. [PDF]
PLoS ONE, 2012 Successive structural changes of bacteriophage λ upon heating were characterized with quantitative experimental methods. In the commonly used Tris-Mg buffer, differential scanning calorimetry measurements first established that the protein capsid of λ ...
Xiangyun Qiu
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Viruses, 2023 Human Cytomegalovirus Capsid Assembly Protein Precursor (pAP, UL80.5) plays a key role in capsid assembly by forming an internal protein scaffold with Major Capsid Protein (MCP, UL86) and other capsid subunits.
Zhigang Zhang +5 more
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The effect of chemical chaperones on the assembly and stability of HIV-1 capsid protein. [PDF]
PLoS ONE, 2013 Chemical chaperones are small organic molecules which accumulate in a broad range of organisms in various tissues under different stress conditions and assist in the maintenance of a correct proteostasis under denaturating environments.
Ayala Lampel +4 more
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Molecular Therapy: Methods & Clinical Development, 2023 Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield a mixture of capsids largely devoid of the transgene (empty capsid) compared with the desired ...
Ohnmar Khanal, Vijesh Kumar, Mi Jin
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A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro. [PDF]
PLoS Pathogens, 2011 The C-terminal domain (CTD) of Hepatitis B virus (HBV) core protein is involved in regulating multiple stages of the HBV lifecycle. CTD phosphorylation correlates with pregenomic-RNA encapsidation during capsid assembly, reverse transcription, and viral ...
Chao Chen +2 more
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