Capsid Proteins are Necessary for Replication of a Parvovirus [PDF]
Journal of Virology, 2020 A bstract Despite tight genetic compression, viral genomes are often organized in functional gene clusters, a modular structure that might favor their evolvability. This has greatly facilitated biotechnological developments, such as the recombinant Adeno-Associated
Labadie, Thomas +4 more
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Neck and capsid architecture of the robust Agrobacterium phage Milano
Communications Biology, 2023 Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the “neck” region, where the DNA-filled capsid is connected to the host-recognizing tail remains poorly ...
Ravi R. Sonani +9 more
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Viruses, 2017 Transmitted by mosquitoes; chikungunya virus (CHIKV) is responsible for frequent outbreaks of arthritic disease in humans. CHIKV is an arthritogenic alphavirus of the Togaviridae family.
Susan C. Jacobs +4 more
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Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss
eLife, 2020 The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal protein define a tunnel, through which DNA is translocated into the capsid.
Oliver W Bayfield +2 more
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The Interaction between the Major Capsid Protein and the Smallest Capsid Protein of Human Cytomegalovirus Is Dependent on Two Linear Sequences in the Smallest Capsid Protein [PDF]
Journal of Virology, 2003 ABSTRACT The assembly of human cytomegalovirus (HCMV) with recombinant systems has not been accomplished. An understanding of specific interactions between individual capsid proteins could point to unique characteristics of the assembly process of HCMV capsids.
Lilin, Lai, William J, Britt
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Assembly of bacteriophage P2 capsids from capsid protein fused to internal scaffolding protein [PDF]
Virus Genes, 2010 Most tailed bacteriophages with double-stranded DNA genomes code for a scaffolding protein, which is required for capsid assembly, but is removed during capsid maturation and DNA packaging. The gpO scaffolding protein of bacteriophage P2 also doubles as a maturation protease, while the scaffolding activity is confined to a 90 residue C-terminal ...
Jenny R, Chang +2 more
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FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking
Cell Reports, 2019 Summary: HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we demonstrate that FEZ1 directly interacts with the HIV-1 capsid
Pei-Tzu Huang +6 more
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Dengue virus capsid protein usurps lipid droplets for viral particle formation. [PDF]
PLoS Pathogens, 2009 Dengue virus is responsible for the highest rates of disease and mortality among the members of the Flavivirus genus. Dengue epidemics are still occurring around the world, indicating an urgent need of prophylactic vaccines and antivirals.
Marcelo M Samsa +7 more
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Iodination of Poliovirus Capsid Proteins
Journal of General Virology, 1977 Summary Iodination of the surface of poliovirus and its artificial empty capsid demonstrated predominant labelling of polypeptide VP 1 on the intact particle and an increased labelling of polypeptide VP 2 on the artificial empty capsid.
T W, Beneke +3 more
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Three-Dimensional Localization of the Smallest Capsid Protein in the Human Cytomegalovirus Capsid [PDF]
Journal of Virology, 2005 ABSTRACT The smallest capsid proteins (SCPs) of the human herpesviruses differ substantially in size and sequence and are thought to impart some unique aspects of infection to their respective viruses. We used electron cryomicroscopy and antibody labeling to show that the 8-kDa SCP of human cytomegalovirus is attached only to major capsid ...
Xuekui, Yu +6 more
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