Results 81 to 90 of about 11,911,049 (290)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A design view of capability [PDF]
, 2008 In order to optimise resource deployment in a rapid changing operational environment, capability has received increasing concerns in terms of maximising the utilisation of resources.
Whitfield, Ian +6 more
core +3 more sources
Problematising the ‘war for talent’: using Sen’s Capability Approach as a new framework for thinking about talent management [PDF]
This article uses Sen’s Capability Approach primarily to conceptualise an evaluative framework for organizational talent management strategies but also to suggest a more human basis for identifying and recognising talent.
Downs, Yvonne, Swailes, Stephen
core +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ho Chi Minh City Open University Journal of Science - Economics and Business AdministrationThis study explores the factors influencing the Human Development Index (HDI) in Asian nations, focusing on Gross National Income (GNI) and the Gender Development Index (GDI) as key determinants.
Ronel Geraldizo Dagohoy +2 more
doaj +1 more source
Education as Change, 2017 By adopting Sen’s capability approach, this study explores transformative educational actions for children in poverty to develop their capabilities for learning for life.
Kyung Hi Kim
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Commensurable freedoms in the capability approach [PDF]
The basis of the capability approach (CA) was recently attacked by a paper by Prasanta Pattanaik and Yonghseng Xu: the CA is strongly committed to two substantial principles, dominance on the one hand, and relativism on the other hand.
Antoinette Baujard
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source