Results 81 to 90 of about 2,190,448 (297)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Commensurable freedoms in the capability approach [PDF]
The basis of the capability approach (CA) was recently attacked by a paper by Prasanta Pattanaik and Yonghseng Xu: the CA is strongly committed to two substantial principles, dominance on the one hand, and relativism on the other hand.
Antoinette Baujard
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
This paper offers a critique of Martha Nussbaum’s description of the capability approach, and offers an alternative. I will argue that Nussbaum’s characterization of the capability approach is flawed, in two ways.
Robeyns, Ingrid
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Twenty-first-century competencies and capabilities for financial accounting students
South African Journal of Economic and Management SciencesBackground: The financial accounting profession faces several challenges in the 21st century. Research is needed to prepare financial accountants for these challenges. Aim: This study aimed to determine which 21st-century competencies were essential for
Elette van den Berg, Sebastiaan Rothmann
doaj +1 more source
A dynamic operationalization of Sen's capability approach [PDF]
The limits of the utilitarian approach have led to a search for different notions of welfare. The income approach to well-being, in fact, doesn’t account for the diversity in human beings and for the heterogeneities of contingent circumstances.
Marco Grasso
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Education as Change, 2017 By adopting Sen’s capability approach, this study explores transformative educational actions for children in poverty to develop their capabilities for learning for life.
Kyung Hi Kim
doaj +1 more source
A capability approach to language education in the Gaza Strip: “To plant hope in a land of despair” [PDF]
, 2017 This article proposes a shift away from competence models (Byram 1997) toward a more holistic approach in language education. Drawing on original critical participatory action research with English teachers in the Gaza Strip (Palestine), Imperiale argues
Imperiale, Maria Grazia
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