Results 101 to 110 of about 254,019 (304)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Human Development Index: A History [PDF]

open access: yes
This article recounts the intellectual history of the UNDP’s Human Development Index. It begins with the early history of welfare economics and follows this field through three successive revolutions in thought, culminating in the theory of human ...
Elizabeth Stanton
core  

Determining the lines of system maturity, system readiness and capability readiness in the system development lifecycle [PDF]

open access: yes, 2009
Many systems suffer from major problems with implementation, integration, performance and other lifecycle problems and unexpected and unacceptable behaviour often arises when they are introduced into the real world, yet the systems were believed to be “
Tetlay, Abideen, John, Philip
core  

A cluster partitioning method considering adjustable capacity and response speed of flexible resources

open access: yes电力工程技术
In order to improve the orderly control and flexible adjustment capabilities of large-scale distributed power sources connected to the distribution network, it is currently an effective method to reasonably divide the distributed power sources into ...
LYU Wenqi   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Computing Multivariate Process Capability Indices With Microsoft Excel

open access: yes
In manufacturing industry there is growing interest in measures of process capability under multivariate setting. While there are many statistical packages to assess univariate capability, a current problem with the multivariate measures of capability is
Michele Scagliarini, Raffaele Vermiglio
core  

Beyond Gdp: Conceptual Grounds of Quantification. The Case of the Index of Economic Well-Being (IEWB) [PDF]

open access: yes
Today, though the need for new indicators of progress is broadly recognized, no consensus has arisen on a successor to GDP. Various – often conflicting – quantification options are observed.
Géraldine THIRY
core  

Measuring the contribution of extractive industries to local development : the case of oil companies in Nigeria [PDF]

open access: yes
Extractive industries face two main challenges in terms of CSR and poverty reduction: 1) recognize that societal activity is part of their core business; 2) take part in socio-economic projects that contribute to their stakeholders' empowerment and not ...
Diongue Abdou Ka   +2 more
core   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

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