Results 81 to 90 of about 254,019 (304)

Mapping sustainable development in a capability perspective [PDF]

open access: yes
The importance of the notion of sustainable development has been advocated, among others, by Amartya Sen. In Sen’s view it is necessary to depart from the general strategy of defining sustainable development only in terms of fulfilment of needs and to ...
Enzo Di Giulio, Marco Grasso
core  

The Relationship Between Hospital Capability and Mortality in Sepsis: Development of a Sepsis-Related Hospital Capability Index. [PDF]

open access: yesCrit Care Med, 2023
Ofoma UR   +6 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Local sustainable development and well-being/quality of life. An application of the capability approach at regional level [PDF]

open access: yes
This paper has a twofold aim: the former is to focus on the concept of well-being/quality of life and its relationships with local sustainable development and the latter is to apply the capability approach at regional level.
Alba Distaso
core  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

A general novel process capability index for normal and non-normal measurements

open access: yesAin Shams Engineering Journal
In this study, a new process capability index is proposed. The new index is quantile-based, can be used in normal and non-normal measurements, and is a general form of the conventional Cpm.
Kadir Karakaya
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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