Results 41 to 50 of about 17,024,608 (281)

Enterprise digital resilience capability framework: an integrated dynamic capability approach

open access: yesEntrepreneurship and Sustainability Issues
This paper addresses how organisations can develop integrated capabilities to withstand digital disruptions while leveraging them strategically. Three critical gaps are identified: treating digital risk management operationally rather than strategically,
Viktoriia Hrosul   +4 more
doaj   +1 more source

Planning for Integrating Teaching Technologies

open access: yesCanadian Journal of Learning and Technology, 2004
Teaching technologies offer pedagogical advantages which vary with specific contexts. Successfully integrating them hinges on clearly identifying pedagogical goals, then planning for the many decisions that technological change demands.
Mandie Aaron   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

HCI engineering integrated with capability maturity models: A study focused on requirements development

open access: yes2016 IEEE Tenth International Conference on Research Challenges in Information Science (RCIS), 2016
Even though coming from different communities, Software Engineering (SE) and Human-Computer Interaction (HCI) engineering have similar goals: the definition of methods, techniques and standards to support the development of software systems, and, in particular for HCI, of interactive systems.
Guidini Gonçalves, Taisa   +2 more
openaire   +2 more sources

Evolution of a Lean Smart Maintenance Maturity Model towards the new Age of Industry 4.0

open access: yesProceedings of the Conference on Production Systems and Logistics, 2020
Over the last few years, the complexity of asset and maintenance management of industrial plants and machinery in the producing industry has risen due to higher competition and volatile environments.
Schmiedbauer, Oliver   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bridging the Capability Gap: A Multidimensional Maturity Model for Smart City Development in German Municipalities

open access: yesUrban Science
Municipal smart city programs remain hampered by conceptual fragmentation and the absence of validated, context-specific maturity assessments. We develop the Smart Municipality Maturity Model (SMMM) via a design-science process, synthesizing 183 ...
Bernhard Koelmel   +3 more
doaj   +1 more source

KEY FACTORS OF PROCESS MATURITY IN ENGLISH-SPEAKING CARIBBEAN FIRMS [PDF]

open access: yesRAE: Revista de Administração de Empresas, 2014
The information system (IS) community has been struggling with the delivery of low quality systems. Software process improvement (SPI) has been accepted as one of the remedies to overcome this problem, with process maturity being a key element.
Delroy Chevers
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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