Results 51 to 60 of about 17,024,608 (281)

Development and evaluation of a maturity assessment tool for integrating building information modelling into operations and maintenance phase of buildings

Developments in the Built Environment
The emergence of advanced digital tools such as building information modelling (BIM) has transformed the concept of building management in the construction sector.
Dania K. Abideen, Akilu Yunusa-Kaltungo, Clara Cheung, Patrick Manu   +3 more
doaj   +1 more source

Information Security Assessment Using ISO/IEC 27001:2013 Standard on Government Institution

Trikonomika, 2018
The purpose of this research is to determine the existing gap to achieve ISO/IEC 27001:2013 certification and determine the maturity level of the information system owned by X Government Institution.
Akmal Zaifullah Maingak, Candiwan Candiwan, Listyo Dwi Harsono   +2 more
doaj   +1 more source

A cloud software life cycle process (CSLCP) model

Ain Shams Engineering Journal, 2021
Small to medium-sized enterprises take advantage of the strengths and opportunities of cloud computing. These enterprises require a well-defined software process model to produce reliable and quality cloud software, given their limited resources ...
Amira A. Alshazly, Mustafa Y. ElNainay, Adel A. El-Zoghabi, Mohamed S. Abougabal   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Capability Maturity Model for Integrated Project Delivery

Buildings
As the adoption of Integrated Project Delivery (IPD) progresses, increasing evidence highlights its potential to improve project outcomes. However, as an emerging practice, there remains a lack of structured mechanisms to evaluate the maturity of its implementation, which can limit opportunities for learning and improvement.
Ahmad J. Arar, Erik Poirier, Sheryl Staub-French   +2 more
openaire   +2 more sources

Developing Digital Service Transformation Maturity Model in Public Sector

IEEE Access
Digital service transformation involves developing or enhancing digital service products within the scope of business transformation. The primary goal is to create or enhance value through the integration of information technology, computing ...
Naufal Fahmi Zakiuddin, Sawung Murdha Anggara, Suhardi   +2 more
doaj   +1 more source

A Maturity Model for Higher Education Institutions [PDF]

Journal of Spatial and Organizational Dynamics, 2013
The adoption of business process improvement strategies is currently a concern of most organizations. The quest for the benefits of this improvement on resource optimization and the responsiveness of the organizations has raised several proposals for ...
Duarte Duarte, Paula Ventura Martins
doaj  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source