Results 71 to 80 of about 17,024,608 (281)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Acta Scientiarum: Technology, 2009 Em Micro e Pequenas Empresas de Software (MPEs), geralmente, não há umprocesso sistemático de desenvolvimento de software. Um dos motivos é que essas empresas consideram os processos tradicionais extensos.
Francisco Virginio Maracci +4 more
doaj
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Cyber Security Maturity Model Capability at The Airports
, 2021 Cybersecurity is an important facilitator for essential aviation safety. The adoption rate for levels of cyber-security protocols at commercial airports is the focus of this research.
Dey, Sharmistha +3 more
core
BuildingsWith the continuous digital transformation of the construction industry, differences in the depth and effectiveness of BIM application during the construction phase of building projects have become increasingly evident.
Ping Cao, Zhencai Wu
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Construction process categorisation towards developing an E-business maturity model [PDF]
, 2014 The rapid pace of change in technology coupled with global economic and environmental changes has had considerable impact on all business sectors. Consequently, organisations are forced to drive towards efficiency savings, productivity improvements and ...
Zhou, Lei +4 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Combining Individual and Organizational Capabilities: An Integrated Maturity Model for Ambidexterity [PDF]
Proceedings of the Annual Hawaii International Conference on System Sciences, 2021 Rocco Xaver Richard Huber +2 more
openaire +2 more sources