Results 91 to 100 of about 10,614 (294)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Fuzzy Multi Attribute Assessment Model for Software Outsourcing Partnership Formation

IEEE Access, 2018
Building on the preceding studies, this paper aims to extend the latest capability maturity model integration (CMMI)-based organization assessment model to the fuzzy environment.
Sikandar Ali, Hongqi Li, Siffat Ullah Khan, Yanhong Zhao, Li Li   +4 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Combining Individual and Organizational Capabilities: An Integrated Maturity Model for Ambidexterity [PDF]

Proceedings of the Annual Hawaii International Conference on System Sciences, 2021
Rocco Xaver Richard Huber, Julia Renner, Bastian Stahl   +2 more
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Development of an AI Governance Model for Higher Education Using the Capability Maturity Model Integration (CMMI)

The increasing adoption of Artificial Intelligence (AI) in higher education presents strategic opportunities for institutional transformation, while introducing complex challenges related to ethics, accountability, transparency, and regulatory compliance.
Surendro, Kridanto, Walhidayah, Irfan
core   +1 more source

Interpreting Capability Maturity Model Integration (CMMI) for Service Organizations: A Systems Engineering and Integration Services Example

, 2018
Capability Maturity Mode Integration (CMMI) provides a framework for improving the processes organizations use to develop, deliver, and maintain products and services.
Mary Anne Herndon (5407007), Laura West (5407010), Julie Walker (5407004), Robert Moore (5407013), D. Michael Phillips (5405471)   +4 more
core   +1 more source

A capability maturity model for assessing digital integration in smart farming

Smart Agricultural Technology
The advancements of smart farming are noteworthy, largely driven by rapid developments in digital technologies such as the Internet of Things, Big Data, and AI. However, the mere availability of these technologies does not guarantee their effective integration into agricultural systems.
Emmanuel Ahoa, Ayalew Kassahun, Cor Verdouw, Bedir Tekinerdogan, Joep Tummers   +4 more
openaire   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source