Results 91 to 100 of about 17,024,608 (281)
Interpreting Capability Maturity Model Integration (CMMI) for Operational Organizations [PDF]
, 2002 Capability Maturity Model Integration (CMMI) provides a framework for improving the processes organizations use to develop and deliver products for their customers. The process improvement concepts embedded in CMMI are based upon sound process management principles used in manufacturing communities for years.
openaire +1 more source
Capability Maturity Model® Integration (CMMI), Version 1.1--Staged Representation
, 2018 Capability Maturity Model Integration (CMMI) models have evolved the Capability Maturity Model (CMM) concept, established by the Capability Maturity Model for Software (SW-CMM), to a new level that enables the continued growth and expansion of the CMM ...
CMMI Product Team (5406056)
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Capability Maturity Model® Integration (CMMI), Version 1.1--Continuous Representation
, 2018 Capability Maturity Model Integration (CMMI) models have evolved the Capability Maturity Model (CMM) concept, established by the Capability Maturity Model for Software (SW-CMM), to a new level that enables the continued growth and expansion of the CMM ...
CMMI Product Team (5406056)
core +1 more source
Assessing the public health informatics workforce in Texas local health departments
Frontiers in Public HealthIntroductionAs health disparities persist and our technological capabilities continue to evolve, a well-trained and representative workforce in public health informatics has become crucial.MethodsA mixed-methods approach with purposive sampling was ...
Rhoda A. Leos +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
IEEE AccessThe adoption of Extreme Programming (XP), a widely recognized Agile methodology, faces numerous barriers that hinder its successful implementation in software development organizations.
Muhammad Faisal Abrar +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source