Results 81 to 90 of about 138,351 (294)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TQM implementation: An empirical examination and proposed generic model [PDF]

, 2001
Total quality management (TQM) is considered by many as an important quality and business performance improvement tool. The popularity of the concept has led to an explosion of TQM related literature.
A Ghobadian, Ahire, Beer, Benson, Boaden, Bright, D Gallear, Easton, Edwards, Eskildson, Feigenbaum, Foster, Gale, Garvin, Ghobadian, Ghobadian, Ghobadian, Glover, Grant, Grant, Hackman, Hannagan, Harte, Harte, Hill, Holder, Johnston, Kanji, Lascelles, Levine, Mann, McCabe, Merli, Mohrman, Motwani, Myers, Newall, Oakland, Parker, Port, Porter, Powell, Rau, Reger, Rigg, Ross, Rue, Seel, Shin, Steele, Summers, Tolchinsky, Wellburn, Whittle, Wilkinson, Wilkinson, Williams, Wilshaw   +57 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

WAEI/MSE: uma instância do processo WAE para micro e pequenas empresas de software = WAEI/MSE: an instance of the WAE process for micro and small software enterprises

Acta Scientiarum: Technology, 2009
Em Micro e Pequenas Empresas de Software (MPEs), geralmente, não há umprocesso sistemático de desenvolvimento de software. Um dos motivos é que essas empresas consideram os processos tradicionais extensos.
Francisco Virginio Maracci, Thelma Elita Colanzi, Andrea Padovan Jubileu, Marcelo Vinícius Creres Rosa, Emanuelle Fabiana Said Branco   +4 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Kesesuaian Capability Maturity Model Integration Development V1.2 (CMMI Dev. V1.2) Terhadap ISO 9001 [PDF]

Kesesuaian CMMI Development V1.2 dengan ISO 9001 merupakan suatu gambaran tentang adanya kesenjangan yang harus ditutup dalam penerapan CMMI pada perusahaan pengembang perangkat lunak, apabila perusahaan pengembang perangkat lunak tersebut telah ...
Astuti, Waniwatining
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Relationship between PDP maturity and ISO certification in the food industry

Gestão & Produção
Food companies have been seeking certification of their Product Development Processes (PDP) as a symbol of quality, however, few are prepared to obtain it.
Lígia de Oliveira Franzosi, Carla Cristina Amodio Estorilio   +1 more
doaj   +1 more source

Fuzzy Multi Attribute Assessment Model for Software Outsourcing Partnership Formation

IEEE Access, 2018
Building on the preceding studies, this paper aims to extend the latest capability maturity model integration (CMMI)-based organization assessment model to the fuzzy environment.
Sikandar Ali, Hongqi Li, Siffat Ullah Khan, Yanhong Zhao, Li Li   +4 more
doaj   +1 more source