Results 81 to 90 of about 171,183 (310)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Delay-balanced smart repeaters for on-chip global signaling. [PDF]
, 2007 In this paper we propose a smart driver, whose drive strength is dynamically altered depending on the relative bit pattern, by partitioning it into a main driver and assistant driver. For a higher effective load capacitance both drivers switch, while for
Zheng, Li-Rong, +11 more
core +1 more source
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Modelling and analysis of crosstalk in scaled CMOS interconnects [PDF]
, 1995 The development of a general coupled RLC interconnect model for simulating scaled bus structures m VLSI is presented. Several different methods for extracting submicron resistance, inductance and capacitance parameters are documented.
Mahoney, Patrick Francis
core
The measurement of resonant electrical circuit parameters
Известия высших учебных заведений. Поволжский регион:Технические науки, 2021 Background. The purpose of the study is to develop techniques for measuring three- and four-element resonant electrical circuit parameters. Materials and methods.
A.V. Svetlov, N.M. Nguyen
doaj +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Impurities Limit the Capacitance of Carbon Based Supercapacitors
, 2018 Supercapacitors cannot fulfill their potential as energy storage devices without substantially improving their comparatively low energy density. This requires improving their capacitance.
Xiu Song Zhao (5802676) +5 more
core +1 more source
Energies, 2020 Supercapacitors, one of the most promising energy storage technologies for high power density industrial applications, exchange the energy mostly through power electronic converters, operating under high frequency components due to the commutation.
Gustavo Navarro +5 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein +7 more
wiley +1 more source
Extraordinary Capacitance and Stability of Carbon Electrode for Electrochemical Capacitors
ElectrochemistryTo further improve the energy density and reliability of carbon based electrochemical capacitors, such as electric double-layer capacitors and lithium ion capacitors, it is necessary to increase both the electric double layer capacitance and stability of
Soshi SHIRAISHI +3 more
doaj +1 more source