Results 91 to 100 of about 26,738 (304)

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, EarlyView.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Estimation of abnormal states in shunt capacitor banks using transient disturbance feature extraction

Frontiers in Energy Research
Shunt capacitor banks are essential for reactive power compensation, ensuring voltage stability, and reducing system losses. These banks consist of multiple units with components in series and parallel.
Long Zhang, Ming Ma, Wen Xiao, Yunping Zhong, Bi Hu, Wenwen Zhou, Wenhai Zhang   +6 more
doaj   +1 more source

Process for making diamonds [PDF]

, 1973
A description is given of a device and process for making industrial diamonds. The device is composed of an exponential horn tapering from a large end to a small end, with a copper plate against the large end.
Estes, M. F., Rasquin, J. R.
core   +1 more source

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

A Reconfigurable Voltage Converter With Split-Capacitor Charging and Energy Recycling for Ultra-Low-Power Applications

IEEE Access, 2018
This paper presents a reconfigurable on-chip switched capacitor (SC) voltage converter aimed at ultra-low- power applications. The proposed voltage converter provides an additive advantage of energy saving during both sleep-to-active and active-to-sleep ...
Syed Asmat Ali Shah, Saad Arslan, Hyungwon Kim   +2 more
doaj   +1 more source

Cause Identification of Electromagnetic Transient Events using Spatiotemporal Feature Learning

, 2019
This paper presents a spatiotemporal unsupervised feature learning method for cause identification of electromagnetic transient events (EMTE) in power grids.
Arghandeh, Reza, Hamidi, Reza Jalilzadeh, Livani, Hanif, Niazazari, Iman   +3 more
core  

Pinch‐Off Mechanism of High‐Gain Organic Transistors with Field Plates: Statistical Analysis, Device Simulations and Compact Modeling

Advanced Electronic Materials, EarlyView.
Statistical analysis of over 3000 devices reveals a novel operating mechanism in printed organic thin‐film transistors featuring a grounded field plate beneath the source. The field plate governs the low and tunable pinch‐off, enabling excellent current saturation and ultra‐high gain.
Kazuki Ono, Ryota Kobayashi, Eva Bestelink, Radu A. Sporea, Satoru Inoue, Yudai Hemmi, Yuji Ikeda, Tatsuo Hasegawa, Hiroyuki Matsui   +8 more
wiley   +1 more source

Analysis of Expediency to Apply LCL Model with Source of Higher Harmonics of Current While Investigating Resonance Condition of Power Supply Network

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2004
The paper considers a power system model of a plant with one capacitor bank and with one current source of higher harmonics for higher power factor. The laboratory research results of this system and practical application of the proposed model are given ...
M. Pavlovsky, A. Shimansky, Z. Fialkovsky   +2 more
doaj   +1 more source