Results 131 to 140 of about 5,731,628 (253)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Creating Youth Development Systems that Include Youth with Disabilities (NCSET Capacity Building Institute)

, 2001
A transcript of a Capacity Building Institute (CBI) that was an opportunity for key community stakeholders in education, workforce development, and disability services to examine how to better align the various youth development investment systems so ...
National Center on Secondary Education and Transition
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

A Transition Odyssey Technical Assistance about Transition and the Rehabilitation Act (NCSET Capacity Building Institute)

, 2001
A transcript of a Capacity Building Institute (CBI) that was sponsored by NCSET and PACER Center. It included nationally recognized speakers on transition planning and discussion groups focusing on parent involvement in postsecondary education ...
National Center on Secondary Education and Transition
core  

Capacity Building for Community Development among Educators in Guatemala [PDF]

, 2013
This study reports on a multi-year capacity building research partnership between the Center for Child and Community Development a Guatemalan non-profit and public schools in State of Sacatep quez in Guatemala We explore finding from phase 1 of the ...
Hector H. Rivera
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Preparing Youth with Disabilities for Successful Participation in Postsecondary Education and Employment (NCSET Capacity Building Institute)

, 2001
A transcript of a Capacity Building Institute (CBI) that was sponsored by NCSET and the National Center for the Study of Postsecondary Educational Supports.
National Center on Secondary Education and Transition
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Supporting Youth with Disabilities Across Secondary School, Postsecondary School and Employment (NCSET Capacity Building Institute)

, 2002
A transcript of a Capacity Building Institute (CBI) that was co-sponsored by NCSET and the National Center for the Study of Postsecondary Educational Supports It consisted of several different components: online readings and discussion with authors and ...
National Center on Secondary Education and Transition
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source