Results 61 to 70 of about 2,918,690 (278)
BMC Health Services Research, 2018 Background To evaluate the performance of a novel triage system for Transient Ischemic Attack (TIA) units built upon an existent clinical prediction rule (CPR) to reduce time to unit arrival, relative to the time of symptom onset, for true TIA and minor ...
Maximilian B. Bibok +8 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
BMC Health Services ResearchBackground Despite the high demand for public services globally, ensuring the quality of services provided by public health facilities is challenging.
Kizito Kayumba +14 more
doaj +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Uganda: Data Strategy and Capacity Building [PDF]
, 2017 As part of Uganda's commitment to the Sustainable Development Agenda, the country has made substantial progress toward improved national development data—including the launch of a Development Data Hub supported by Development Initiatives and a review of ...
core
Capacity building efforts and perceptions for wildlife surveillance to detect zoonotic pathogens: comparing stakeholder perspectives. [PDF]
, 2014 BackgroundThe capacity to conduct zoonotic pathogen surveillance in wildlife is critical for the recognition and identification of emerging health threats.
Goldstein, Tracey +5 more
core +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Infrastructure Development and Financing in Sub-Saharan Africa: Toward a framework for capacity enhancement [PDF]
, 2016 Of the world’s developing regions, Sub-Saharan Africa has the worst infrastructure deficit, with studies pointing to lost growth opportunities. This study presents in one document information previously dispersed on the region’s infrastructure stock and ...
African Capacity Building Foundation
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
African Union Agenda 2063: Capacity Development Plan Framework: Buttressing Implementation of the First 10-Year Plan - “The Africa We Want” [PDF]
, 2016 During the AU Golden Jubilee Summit, Member States pledged to commit themselves to the continent’s development and technological transformation through a continental strategic framework, Agenda 2063, and to national development plans through a people ...
African Capacity Building Foundation
core +1 more source