Results 81 to 90 of about 583,418 (306)

Foreword

Jàmbá, 2009
The conditions prevailing in the world, where fast growing populations are coupled with rapidly expanding urbanization and a general increase in poverty levels, are greatly aggravating the disaster risks and vulnerabilities of a large part of the world’s
Mmaphaka Tau
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Transport Sector : A Laboratory for Good Practices in Capacity Development?

, 2006
As articulated in the Paris Declaration on Aid Effectiveness (2005), country capacity is at the core of sustainable development.
Davis, Deborah
core   +1 more source

Criminal Law (Amendment) Act, 2013: Will it ensure women’s safety in public spaces?

Space and Culture, India, 2013
The horrific gang-rape and the subsequent murder of Nirbyaya (fearless) in December 2012, impelled the Government of India to pass the Criminal Law (Amendment) Act, 2013. The key aim of this article is to review this Act in the light of women's safety in
Rituparna Bhattacharyya
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Capacity building: shifting the paradigms of practice

, 2000
Capacity building is now one of the most frequently invoked of current development concepts and yet it continues to defy a shared definition of what it means in practice. Is it possible that capacity building demands such a radically new form of practice,
Kaplan, Allan
core   +1 more source

Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks

BMC Infectious Diseases
Background The Uganda ministry of Health recommends frequent blood glucose monitoring for the first six months on dolutegravir, in people with HIV (PWH) having pre-diabetes mellitus (pre-DM). We sought to determine if indeed PWH with pre-diabetes started
Frank Mulindwa, Jean-Marc Schwarz, Nele Brusselaers, Martin Nabwana, Robert Bollinger, Allan Buzibye, Willington Amutuhaire, George Yendewa, Eva Laker Agnes Odongpiny, Ronald Kiguba, Barbara Castelnuovo   +10 more
doaj   +1 more source

Phytochemical Characterization and Antioxidant, Antimicrobial, and Poultry Meat Preservation Potential of Ziziphus mauritiana

Foods
Consumer preference for clean-label products is driving interest in natural antioxidants and antimicrobials that can replace synthetic preservatives. Ziziphus mauritiana (sidr), a resilient desert tree native to the arid Gulf region, has being tested as ...
Mohamed Gamal Shehata, Hassan Mohamed Al Marzooqi, Hanan Sobhy Afifi, Saad H. D. Masry   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source