Results 91 to 100 of about 583,418 (306)
, 2002 A transcript of a Capacity Building Institute (CBI) that provided researchers, leaders, policy makers, and national experts an opportunity to engage in a dialogue on current views, build consensus on critical issues, and generate solutions and strategies.
National Center on Secondary Education and Transition
core
Capacity-Building in Community-Based Drug Treatment Services
, 2022 Globally, there are not enough services to meet the enormous demand for evidence-based community-based drug treatment. Further, the effectiveness of available services varies as much as the diversity of their treatment regimens.
Cole, Michael J, Cole, Michael J.
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
, 2003 A transcript of a Capacity Building Institute (CBI) that provided information, resources, and training regarding the issues, service provision, and alternative methodologies for addressing youth with disabilities involved with the juvenile justice system.
National Center on Secondary Education and Transition
core
A Theoretical Field Study within the Discipline of Sociology of Education
Zanco Journal of Humanity SciencesLanguage is seen as a dynamic component of social culture and is ever evolving. From a societal perspective, language has more purposes than just conveying information.
Chnar Saad Abdulla
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Risky business: capacity-building in collaborative research
, 2010 The concept of capacity-building, originating in studies of economic development, operates as a powerful metaphor in arguments promoting collaborative research in education.
Midgley, Warren, Danaher, Patrick Alan
core
International Journal of Disaster Risk Science, 2017 This preliminary study examines the definition problem and challenges of climate forecasting and disaster responses associated with the El Niño costero (coastal) of 2017, which developed rapidly with no warning and had catastrophic effects in Peru.
Ivan J. Ramírez, Fernando Briones
doaj +1 more source