Results 131 to 140 of about 221,610 (308)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Optimal Configuration of Distributed Pumped Storage Capacity with Clean Energy [PDF]

Aiming at the economic problems of industrial users with wind power, photovoltaic, and small hydropower resources in clean energy consumption and trading with superior power grids, this paper proposes a distributed pumped storage capacity optimization ...
Yongjia Wang, Xun Li, Zhenhui Ouyang, Hao Zhong, Wenzhuo Hu   +4 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Optimization Configuration of Leasing Capacity of Shared-Energy-Storage Systems in Offshore Wind Power Clusters [PDF]

A double-layer robust optimization method for capacity configuration of shared energy storage considering cluster leasing of wind farms in a market environment is proposed based on the autonomy and profitability of shared energy storage.
Jiekang Wu, Yuanyuan Lou, Zhen Lei
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Parametric Model for Operability of Offshore Support Vessels via Configuration-Based Design [PDF]

, 2014
TCC (graduação) - Universidade Federal de Santa Catarina. Campus Joinville. Engenharia Naval.O propósito das embarcações de apoio offshore (OSV’s) é dar suporte a indústria do petróleo para várias atividades no mar, como abastecimento, manuseio de âncora,
Vidal, Hugo Luckmann
core  

A Capacity Allocation Method for Long-Endurance Hydrogen-Powered Hybrid UAVs Based on Two-Stage Optimization

Algorithms
Due to the challenges associated with the application of existing two-stage optimization methods in energy system capacity configuration, such as uncertainty scenario generation, multi-timescale coupling, and balancing economic and environmental benefits,
Haitao Li, Chenyu Wang, Shufu Yuan, Hui Zhu, Li Sun   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Optimal configuration of hydrogen storage capacity of hybrid microgrid considering peak regulation and frequency modulation requirements [PDF]

This study proposes an innovative hydrogen storage capacity optimization configuration method that considers multiple demand factors, addressing the issue that traditional methods for optimizing hydrogen storage capacity in hybrid microgrids cannot ...
Yuhan Guo, Weijun Zhu, Dan Yu
core   +1 more source