Results 141 to 150 of about 221,610 (308)

Energy Storage Capacity Configuration and Scheduling Method for Microgrid Considering Demand Response

Energies
In recent years, with the development of the electricity market, electricity users have also been able to participate in electricity trading. The energy storage capacity configuration of microgrids with renewable energy considering demand response is of ...
Tingzhe Pan, Chao Li, Xin Jin, Zijie Meng, Xinlei Cai   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Optimization Configuration of Hybrid Energy Storage Capacity for Wind Power Fluctuation Smoothing Based on Variational Mode Decomposition

发电技术
ObjectivesTo address the issues of variability and intermittency of wind power generation, a configuration scheme of hybrid energy storage system for wind power smoothing is proposed.
ZHANG Ping, LI Yongqiang, XING Hualiang
doaj   +1 more source

PASS-Based Multi-User Communications: Capacity Characterization and Configuration Strategy

IEEE Transactions on Communications
The fundamental capacity limits of pinching-antenna systems (PASS)-based multi-user communication network are investigated. Two practical pinching-antenna configuration strategies are considered, namely multiple-time discrete activation and one-off continuous sliding.
Yuquan Xiao, Xidong Mu, Yuanwei Liu, Qinghe Du, Arumugam Nallanathan   +4 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dynamic-Depreciation-Aware Bi-Level Capacity Optimization of Shared Energy Storage for Renewable Energy Bases Considering Multi-Service Operation

Energies
Shared energy storage (SES) in renewable energy bases can integrate reliability support, curtailed-energy accommodation, spot-market arbitrage, and frequency-regulation services, but unclear service boundaries and static depreciation may distort capacity-
Yu Wang, Mengyang Huang, Tianqi Xu, Jindi Zhang, Pengfei Li   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optimization of Multi-Type Energy Storage Systems Capacity Configuration via an Improved Projection-Iterative Optimizer

Applied Sciences
An improved optimizer based on projection-iterative methods (IPIMO) is proposed to address the optimal configuration problem of multi-type energy storage systems (MT-ESS), with the objective of achieving synergistic minimization of comprehensive costs ...
Sile Hu, Dandan Li, Yu Guo, Jiaqiang Yang, Bingqiang Liu, Xinyu Yang   +5 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source