Results 151 to 160 of about 221,610 (308)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Two-stage robust optimization configuration of comprehensive energy system for the new energy town
电力工程技术A two-stage robust optimization configuration strategy for the new energy town is proposed to address the issue of insufficient power supply reliability in integrated energy systems due to the fluctuation and intermittency characteristics during the ...
Li HU, Jing CHENG
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
工程科学与技术ObjectiveLeveraging the regulatory and energy storage capabilities of hydropower and pumped storage to mitigate the fluctuations in wind and photovoltaic output has emerged as a novel model supporting large-scale development of new energy, high ...
HE Junqi +4 more
doaj
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
The effect of spatial configuration of habitat capacity on β diversity [PDF]
Patterns of β diversity are commonly used to infer underlying ecological processes. In this study, we examined the effect of spatial configuration of habitat capacity on different metrics of β diversity, i.e., β diversity measured as turnover and as ...
Muneepeerakul, R. +3 more
core +1 more source
Communication capacity of a free space laser communication system in atmospheric turbulent and disperse channels [PDF]
, 2011 The pulse broadening and communication capacity in atmospheric turbulent and disperse channels are investigated. Models on pulse broadening are proposed, and the simulated results for a typical atmospheric condition and configuration are provided.
Lu Hongqiang +3 more
core
Renmin ZhujiangThe large-scale integration of variable renewable energy (VRE) has significantly exacerbated the urgent need for flexible regulation capabilities in modern power systems.
ZHANG Yutang, SHEN Jianjian, WANG Yue
doaj
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source