Results 91 to 100 of about 3,458,179 (303)

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

open access: yesAdvanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng   +14 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang   +5 more
wiley   +1 more source

Assignments - A Cultural Awakening at the BCC [PDF]

open access: yes, 2013
6th Annual Cultural Arts Festival commemorating the 10th anniversary of the BCC.Front page cover of the program containing a list of activities scheduled for the commemorative celebration.No ...
Purdue University Black Cultural Center
core  

Leveraging organisational cultural capital

open access: yesSA Journal of Industrial Psychology, 2007
Organisational culture discourse mandates a linear approach of diagnosis, measurement and gap analysis as standard practice in relation to most culture change initiatives. Therefore, a problem solving framework geared toward “fixing ?
R Scheel, F Crous
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

open access: yesAdvanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao   +10 more
wiley   +1 more source

Improving natural capital: an assessment of progress [PDF]

open access: yes, 2019
This is the final version. Available from Defra via the link in this record.This report sets out the work done by the committee since March 2016. It also makes a series of recommendations to government on developing the 25 year environment plan.
Natural Capital Committee
core  

Learning Work Function via Implicit Reasoning on Electrostatic Potential Landscapes

open access: yesAdvanced Science, EarlyView.
StructPot‐CLR establishes a cross‐modal contrastive learning framework that aligns the crystal structures of 2D materials with plane‐averaged electrostatic potential landscapes for physically informed work‐function prediction. The model achieves an MAE of 0.265 eV and an R2 of 0.902 on the held‐out test set while accurately preserving key morphological
Haoyu Wan, Yue Wu, Tianhao Su, Deng Pan
wiley   +1 more source

Operationalising ecosystem services: advancing knowledge on natural and cultural capital [PDF]

open access: yes, 2018
contact with nature induces many different feelings, both positive and negative. on the negative side, people can suffer from allergies from flowering plants, many insect species can cause physical harm or spread disease (lyytimäki and sipilä, 2009) and ...
Smith, Alison   +13 more
core  

UN ESTUDIO ETNOGRÁFICO DE LAS PRÁCTICAS DE RESISTENCIA HACIA LA CULTURA ESCOLAR EN TRES INSTITUCIONES EDUCATIVAS DE BÁSICA SECUNDARIA EN LA CIUDAD DE CALI

open access: yesEntramado, 2010
El artículo tiene como objetivo general describir desde un enfoque cualitativo los comportamientos y actitudes de resistencia a la cultura escolar de los estudiantes de tres instituciones educativas de básica secundaria, de estratos uno, dos y tres en la
Holbein Giraldo Paredes
doaj  

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao   +12 more
wiley   +1 more source

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