Results 101 to 110 of about 170,896 (301)

Made in a European Capital of Culture

, 2013
Der Beitrag behandelt den internationalen Wettbewerb "Made in", der im Rahmen der Kulturhauptstadt Guimaraes 2012 zur Reaktivierung der öffentlichen Waschplätze als kulturelles Erbe im urbanen Raum von Guimaraes/ Portugal durchgeführt wurde ...
Holub, Barbara
core  

Asymmetrically Coordinated Dual‐Atom Manganese Contrast Agents Enabling High‐Efficiency T1 Enhanced MRI for Precise Tumor Visualization

Advanced Science, EarlyView.
A novel dual‐atom manganese MRI contrast agent (Mn‐BN) with a unique asymmetric coordination geometry provided a promising platform for sensitive and specific tumor imaging. In mice model, Mn‐BN nanoparticles precisely functioned as both a primary tumor‐specific enhancer in subcutaneous models and a hepatocyte‐specific agent in liver metastases models ...
Ding Yang, Qing‐Yang Li, Jianli Liang, Gengyou Li, Nan Sun, Qianqian Song, Haitao Zhu, Xiaoting Li, Zechuan Li, Jiankai Dong, Weisheng Guo, Yafang Xiao, Chun‐Sing Lee, Ying‐Shi Sun   +13 more
wiley   +1 more source

Drop‐Shaped Optical Microfiber Enabled Biomechanical Sensor

Advanced Science, EarlyView.
A novel microforce sensor based on a drop‐shaped optical microfiber is presented herein, designed to characterize the biomechanical properties of single cells and microscale living organisms, achieving a force resolution of 24 nN. Leveraging its high sensitivity, facile miniaturization, excellent flexibility, and robust mechanical stability, this ...
Yan Xu, Xitao Tu, Haochen Jiang, Jun Mo, Xinyue Zhang, Xiaomin Yue, Limin Tong, Lei Zhang   +7 more
wiley   +1 more source

Mediation Effect of Cultural Capital on the Influence of Human Resources Capital and Physical Resources Capital Towards Regional Financial Condition of the Government of South Sulawesi

, 2015
in the context of regional development, the government's role as an actor mainly be carried out by the government through expenditures are able to directly encourage the movement of the economy, both at national and local level.
Nirwana
core  

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Ten years of cultural development in Sibiu: The European cultural capital and beyond

This study presents the results of a ten year monitoring programme on cultural and tourism development in the city of Sibiu. Over the ten year research period the programme expanded to cover a wide range of data sources, including resident and visitor ...
Richards, Greg, Rotariu, Ilie
core  

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Multilingüisme en famílies mixtes amb persones d’origen estranger a Catalunya

Treballs de Sociolingüística Catalana, 2018
Catalunya ha experimentat un augment significatiu en les unions mixtes entre immigrants i nadius, les quals han donat lloc a un nombre creixent de persones amb orígens mixtos.
Miguel Solana Solana, Anna Ortiz Guitart, Dan Rodríguez García   +2 more
doaj  

Condiciones del desarrollo del aprender a aprender como factores de inserción laboral de egresados de licenciatura

RECIE Revista Electrónica Científica de Investigación Educativa
El mercado laboral mexicano de profesionistas presenta problemas de equilibrio, la oferta de profesionistas es mayor que la demanda, esto genera problemas de competencia por los puestos disponibles.
Jorge Ariel Ramírez Pérez
doaj   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source