Results 121 to 130 of about 2,608,452 (296)
Advanced Science, EarlyView.Astrocytic TIA1‐mediated stress granules (SGs) promote demyelination by sequestering the mRNA of cholesterol synthesis genes. In this model, astrocytic TIA1‐mediated SGs were increased in the optic nerves of EAE mice, leading to the downregulation of cholesterol synthesis genes such as HMGCS1 through sequestration of their mRNA into SGs, which ...
Zheyu Fang +11 more
wiley +1 more source
Catastrophic Shocks and Capital markets: A Comparative Analysis by Disaster and Sector [PDF]
This paper provides an analysis of the impact of natural, industrial and terrorist disasters on the Australian capital market using the Box and Tiao intervention analysis and the data on daily returns in the following ten market sectors: consumer ...
Valadkhani, Abbas, Worthington, Andrew
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MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity
Advanced Science, EarlyView.During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen +12 more
wiley +1 more source
OPTIMAL SUBSTITUTION OF RENEWABLE AND NONRENEWABLE NATURAL RESOURCES IN PRODUCTION [PDF]
A theoretical model is presented in order to study the optimal combination of natural resources, used as inputs, taking into account their natural growth ability and the technical possibilities of input substitution.
Emilio Cerdá, Francisco J. André
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Advanced Science, EarlyView.The heterostructure benefits from the high dispersion of FeOx nanoclusters on the porous CoxP substrate, while the interfacial bonds Fe‐O‐Co enhance charge transport and redistribution, resulting in excellent oxygen evolution reaction performance and strong potential for practical applications.
Cheng Gong +11 more
wiley +1 more source
Mozambique and natural disasters: human capital under threat [PDF]
This paper assesses the effect of a sequence of natural disasters on children’s health that hit Mozambique at the start of the 21st Century. The disasters in question were the floods of 2000 and the droughts of the years 2002 and 2003.
Prado C. Alfaiate, Jorge
core +1 more source
Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli
Advanced Science, EarlyView.An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng +6 more
wiley +1 more source
Distributive impact of structural change: does environmental degradation matter? [PDF]
Vulnerability to reduction of natural capital depends on defensive substitution possibilities that, in turn, are affected by the availability of other productive factors.
Angelo Antoci, Elisa Ticci, Paolo Russu
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The state of natural capital: protecting and improving natural capital for prosperity and wellbeing [PDF]
, 2019 This is the final version. Available from Defra via the link in this record.This is the Natural Capital Committee’s (NCC) third report to government. The report sets out recommendations to achieve government’s vision, ‘to be the first generation to leave
Natural Capital Committee
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Advanced Science, EarlyView.Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang +9 more
wiley +1 more source