Results 11 to 20 of about 95,314 (260)

RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2’-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION

African Journal of Infectious Diseases, 2022
Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host’s immune system.
A. Rowaiye, A. Oli, O. Onuh, N. W. Emeter, D. Bur, O. A. Obideyi, Oluyomi Cornelius Dayisi, J. N. Akpa, Lovelyn Birah, Edward E. Omaka¹, Frances Otibhor Iseghohi¹, A. Otitoju, P. Uzor, J. Okoyeh   +13 more
semanticscholar   +1 more source

Active Site Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly [PDF]

, 2017
Xylan-degrading enzymes are crucial for the deconstruction of hemicellulosic biomass, making the hydrolysis products available for various industrial applications such as the production of biofuel.
de Kruijff, Goswinus H. M., Pfrengle, Fabian, Ruprecht, Colin, Schuhmacher, Frank, Seeberger, Peter H., Senf, Deborah, Simonetti, Sebastián Osvaldo   +6 more
core   +1 more source

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. [PDF]

, 2020
Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified.
Ade, C.P., Baluapuri, A., Chang, Y.C., Cossa, G., Eilers, M., Girard, C., Kempa, S., Kumar, A., Kuster, B., Lührmann, R., Mastrobuoni, G., Mumberg, D., Prinz, F., Roeschert, I., Schülein-Völk, C., Silveira Vidal, R., Walz, S., Wolf, E., Wortmann, L.   +18 more
core   +1 more source

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability [PDF]

, 2012
Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation ...
Alabi, Christopher A., Anderson, Daniel Griffith, Chen, Delai, Eltoukhy, Ahmed A., Langer, Robert S   +4 more
core   +1 more source

Biomimetic microelectronics for regenerative neuronal cuff implants [PDF]

, 2015
Smart biomimetics, a unique class of devices combining the mechanical adaptivity of soft actuators with the imperceptibility of microelectronics, is introduced.
Baunack, Stefan, Karnaushenko, Daniil, Karnaushenko, Dmitriy D, Koch, Britta, Makarov, Denys, Meyer, Anne K, Münzenrieder, Niko, Petti, Luisa, Schmidt, Oliver G, Tröster, Gerhard   +9 more
core   +1 more source

The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Histone deacetylase 3 (HDAC3) is a potential target for the treatment of human diseases such as cancers, diabetes, chronic inflammation and neurodegenerative diseases.
Jie Xia, Huabin Hu, Wenjie Xue, Xiang Simon Wang, Song Wu   +4 more
doaj   +1 more source

Characterization of S-100b Binding Epitopes. IDENTIFICATION OF A NOVEL TARGET, THE ACTIN CAPPING PROTEIN, CapZ (*)

Journal of Biological Chemistry, 1995
Short amino acid sequences that interact with the Ca binding protein S-100b were identified by screening a bacteriophage random peptide display library. S-100b binding bacteriophages were selected by Ca-dependent affinity chromatography, and the sequence
V. Ivanenkov, G. A. Jamieson, E. Gruenstein, R. Dimlich   +3 more
semanticscholar   +1 more source

Identification of Small Molecules that Enhance Synaptogenesis Using Synapse Microarrays [PDF]

, 2013
Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads.
Ghosh, Balaram, Haggarty, Stephen John, Mazitschek, Ralph, Scott, Mark A, Shi, Peng, Wan, Dongpeng, Wissner-Gross, Zachary, Yanik, Mehmet Fatih   +7 more
core   +1 more source

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library [PDF]

, 2014
A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques.
Akella, Lakshmi B., Donckele, Etienne, Gerard, Baudouin, Jacobsen, Eric N., Kesavan, Sarathy, Marcaurelle, Lisa A., O’Shea, Morgan Welzel, Xu, Hao   +7 more
core   +1 more source

mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae.

Journal of Biological Chemistry, 1992
The highly purified yeast mRNA capping enzyme is composed of two separate chains of 52 (alpha) and 80 kDa (beta), responsible for the activities of mRNA guanylyltransferase and RNA 5'-triphosphatase, respectively (Itoh, N., Yamada, H., Kaziro, Y., and ...
Y. Shibagaki, Y. Shibagaki, N. Itoh, N. Itoh, Hisafumi Yamada, Hisafumi Yamada, S. Nagata, K. Mizumoto, K. Mizumoto   +8 more
semanticscholar   +1 more source