Results 11 to 20 of about 84,218 (260)

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

SLAS Discovery, 2021
The COVID-19 pandemic has clearly brought the healthcare systems worldwide to a breaking point, along with devastating socioeconomic consequences.
Kanchan Devkota, M. Schapira, Sumera Perveen, Aliakbar Khalili Yazdi, Fengling Li, Irene Chau, P. Ghiabi, T. Hajian, P. Loppnau, Albina Bolotokova, Karla J. F. Satchell, Ke Wang, Deyao Li, Jing Liu, D. Smil, M. Luo, Jian Jin, P. Fish, P. Brown, M. Vedadi   +19 more
semanticscholar   +2 more sources

RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2’-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION

African Journal of Infectious Diseases, 2022
Background: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host’s immune system.
A. Rowaiye, A. Oli, O. Onuh, N. W. Emeter, D. Bur, O. A. Obideyi, Oluyomi Cornelius Dayisi, J. N. Akpa, Lovelyn Birah, Edward E. Omaka¹, Frances Otibhor Iseghohi¹, A. Otitoju, P. Uzor, J. Okoyeh   +13 more
semanticscholar   +1 more source

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability [PDF]

, 2012
Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation ...
Alabi, Christopher A., Anderson, Daniel Griffith, Chen, Delai, Eltoukhy, Ahmed A., Langer, Robert S   +4 more
core   +1 more source

Biomimetic microelectronics for regenerative neuronal cuff implants [PDF]

, 2015
Smart biomimetics, a unique class of devices combining the mechanical adaptivity of soft actuators with the imperceptibility of microelectronics, is introduced.
Baunack, Stefan, Karnaushenko, Daniil, Karnaushenko, Dmitriy D, Koch, Britta, Makarov, Denys, Meyer, Anne K, Münzenrieder, Niko, Petti, Luisa, Schmidt, Oliver G, Tröster, Gerhard   +9 more
core   +1 more source

Characterization of S-100b Binding Epitopes. IDENTIFICATION OF A NOVEL TARGET, THE ACTIN CAPPING PROTEIN, CapZ (*)

Journal of Biological Chemistry, 1995
Short amino acid sequences that interact with the Ca binding protein S-100b were identified by screening a bacteriophage random peptide display library. S-100b binding bacteriophages were selected by Ca-dependent affinity chromatography, and the sequence
V. Ivanenkov, G. A. Jamieson, E. Gruenstein, R. Dimlich   +3 more
semanticscholar   +1 more source

The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Histone deacetylase 3 (HDAC3) is a potential target for the treatment of human diseases such as cancers, diabetes, chronic inflammation and neurodegenerative diseases.
Jie Xia, Huabin Hu, Wenjie Xue, Xiang Simon Wang, Song Wu   +4 more
doaj   +1 more source

Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library [PDF]

, 2014
A 2328-membered library of 2,3,4-trisubstituted tetrahydroquinolines was produced using a combination of solution- and solid-phase synthesis techniques.
Akella, Lakshmi B., Donckele, Etienne, Gerard, Baudouin, Jacobsen, Eric N., Kesavan, Sarathy, Marcaurelle, Lisa A., O’Shea, Morgan Welzel, Xu, Hao   +7 more
core   +1 more source

Identification of Small Molecules that Enhance Synaptogenesis Using Synapse Microarrays [PDF]

, 2013
Synaptic function is affected in many brain diseases and disorders. Technologies for large-scale synapse assays can facilitate identification of drug leads.
Ghosh, Balaram, Haggarty, Stephen John, Mazitschek, Ralph, Scott, Mark A, Shi, Peng, Wan, Dongpeng, Wissner-Gross, Zachary, Yanik, Mehmet Fatih   +7 more
core   +1 more source

In Silico Identification of the Potential Natural Inhibitors of SARS-CoV-2 Guanine-N7 Methyltransferase.

RESEARCH RESULTS IN BIOMEDICINE, 2020
The outbreak of the COVID-19 pandemic caused by the SARS-CoV-2 has triggered intense scientific research into the possible therapeutic strategies that can combat the ravaging disease.
A. Rowaiye, O. Onuh, J. Oladimeji-Salami, D. Bur, M. Njoku, N. Ifedilichukwu, Comfort Ojochenemi John, O. Binuyo, Faith Udo Pius   +8 more
semanticscholar   +1 more source

Serum Stabilities of Short Tryptophan- and Arginine-Rich Antimicrobial Peptide Analogs

PLoS ONE, 2010
Background Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization.
L. T. Nguyen, Johnny K. Chau, Nicole A. Perry, L. de Boer, S. Zaat, H. Vogel   +5 more
semanticscholar   +1 more source