Results 41 to 50 of about 5,089 (214)

Structural Insight into NS5 of Zika Virus Leading to the Discovery of MTase Inhibitors

, 2016
Zika virus (ZIKV) is an emerging mosquito-borne virus recently linked to intrauterine growth restriction including abnormal fetal brain development. The recent outbreak of ZIKV reached pandemic level resulting in an alarming public health emergency.
Guy Boivin (12392), Mariana Baz (245354), Preyesh Stephen (114988), Sheng-Xiang Lin (181047)   +3 more
core   +1 more source

Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. [PDF]

, 2010
Several short antimicrobial peptides that are rich in tryptophan and arginine residues were designed with a series of simple modifications such as end capping and cyclization.
Johnny K Chau, Perry Nicole A., Leonie de Boer, Perry, Nicole A., Vogel Hans J., Sebastian A. J. Zaat, Vogel, Hans J., de Boer, Leonie, Hans J Vogel, Nicole A. Perry, Perry, N.A., Nguyen, L.T., de Boer, L., Chau, J.K., Hans J. Vogel, de Boer Leonie, Chau, Johnny K., Zaat, Sebastian A. J., Zaat, S.A.J., Nicole A Perry, Chau Johnny K., Zaat Sebastian A. J., Johnny K. Chau, Vogel, H.J., Leonard T Nguyen, Nguyen, Leonard T., Leonard T. Nguyen, Nguyen Leonard T., Sebastian A J Zaat   +28 more
core   +1 more source

RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2’-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION

, 2022
BACKGROUND: The 2’-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host’s immune system.
Nnaemeka Okoyeh, Jude, F. Omaka, Edward, Emeter, Nkoli W, Okoyeh, Jude Nnaemeka, Uzor, Philip F., Peace Otitoju, Akinbobola, A. Obideyi, Oluwaseun, Dayisi, Oluyomi Cornelius, Iseghohi¹, Frances Otibhor, N. Akpa, Jude, Oli, Angus Nnamdi, Otibhor Iseghohi, Frances, Akpa, Jude N., Birah, Lovelyn, Bur, Doofan, Obideyi, Oluwaseun A., F. Uzor, Philip, Rowaiye, Adekunle B., Cornelius Dayisi, Oluyomi, Onuh, Olukemi A., Omaka¹, Edward E., Otitoju, Akinbobola Peace, W Emeter, Nkoli   +22 more
core   +1 more source

Interlayer Expansion of Bulk MoS2 via Top‐Down Organic Pillaring Enables Tunable Li+ Intercalation and Controlled Solvent Co‐Intercalation

Advanced Functional Materials, EarlyView.
Top‐down organic pillaring expands the interlayer spacing of bulk‐sized MoS2 particles while preserving the bulk morphology. Operando X‐ray diffraction and electrochemical dilatometry show that MoS2‐bulk undergoes solvent co‐intercalation in diglyme electrolyte, causing large structural expansion, while pillared, expanded MoS2 suppresses solvent uptake
Jaehoon Choi, Pakornrum Tulaphon, Franz Jacobi, Kyeonghyeon Nam, Jameela Karol, Mete B. Durukan, Christoph Scheurer, Desirée Leistenschneider, Simon Fleischmann   +8 more
wiley   +1 more source

Time‐Resolved Magnetization Switching Dynamics Driven by Orbital Torques

Advanced Functional Materials, EarlyView.
Du et al. reveal nanosecond magnetization switching driven by orbital currents using time‐resolved Hall detection. The measurements separate domain nucleation from domain wall propagation and show that Joule heating strongly assists switching by lowering energy barriers.
Ao Du, Shilei Ding, Min‐Gu Kang, Marco Hoffmann, Pietro Gambardella   +4 more
wiley   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source

The success of direct pulp capping and pulpotomy in permanent teeth treatment. Systematic literature review.

, 2017
Relevance of the problem and aim of the work. In order to maintain the vitality of the tooth, its function and formation of tooth roots, in case of deep caries or trauma, protective treatment methods – direct pulp capping or pulpotomy can be applied ...
Amankavičiūtė, Gintarė
core  

Studies Toward Measuring Relative Binding Constants for a Ligand-Receptor Interaction with an Electrochemically Addressable Microelectrode Array

, 2010
Small molecule microarrays are powerful tools for high-throughput screening of compound libraries. Binding events are typically detected by fluorescence, using a secondary labeled antibody.
Fellet, Melissae Stuart
core   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

All‐Optical Reconfigurable Physical Unclonable Function for Sustainable Security

Advanced Materials, EarlyView.
An all‐optical reconfigurable physical unclonable function (PUF) is demonstrated using plasmonic coupling–induced sintering of optically trapped gold nanoparticles, where Brownian motion serves as a robust entropy source. The resulting optical PUF exhibits high encoding density, strong resistance to modeling attacks, and practical authentication ...
Jang‐Kyun Kwak, Changgyun Moon, Hyun‐Bin Yu, Sunkook Kim, Dong‐Hwan Kim   +4 more
wiley   +1 more source