Results 51 to 60 of about 938 (119)

The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.

PLoS Genetics, 2013
Appropriate expression of growth-regulatory genes is essential to ensure normal animal development and to prevent diseases like cancer. Gene regulation at the levels of transcription and translational initiation mediated by the Hippo and Insulin ...
Roland Baumgartner, Hugo Stocker, Ernst Hafen   +2 more
doaj   +1 more source

Japanese encephalitis virus core protein inhibits stress granule formation through an interaction with Caprin-1 and facilitates viral propagation. [PDF]

J Virol, 2013
ABSTRACT Stress granules (SGs) are cytoplasmic foci composed of stalled translation preinitiation complexes induced by environmental stress stimuli, including viral infection. Since viral propagation completely depends on the host translational machinery, many viruses have evolved to circumvent the induction of SGs or co-opt SG ...
Katoh H, Okamoto T, Fukuhara T, Kambara H, Morita E, Mori Y, Kamitani W, Matsuura Y.   +7 more
europepmc   +4 more sources

Unveiling human–wildlife interactions in the context of livestock grazing abandonment and the return of large carnivores, ungulates and vultures: A stakeholder perspective

People and Nature, EarlyView.
Abstract Pastoral practices remain a widespread economic activity across European mountain regions. However, the viability of this activity may be threatened by the recovery of large wild vertebrates associated with passive rewilding, leading to the so‐called human–wildlife conflicts.
P. Acebes, F. J. Muñoz‐Gálvez, Z. Iglesias‐González, M. García‐Llorente, D. López‐García   +4 more
wiley   +1 more source

Small Ruminant Farming in Benin: Characterization, Knowledge and Practices of Breeders Facing Peste des Petits Ruminants

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
A study on small ruminant farmers' knowledge identified three profiles (G1, G2, G3): the majority, young men, favor the Djallonké breed due to its affordability. While groups G1 and G2 showed a low level of knowledge due to extensive farming practices, group G3 stood out.
Ganiou Guedegbe, Jacques Sourou Adouko, José Adoko, Nestor Noudeke, Camus Adoligbe, Yannick Ayihou, Hassane Adakal, Souaïbou Farougou   +7 more
wiley   +1 more source

hnRNPA2B1 represses the disassembly of arsenite-induced stress granules and is essential for male fertility

Cell Reports
Summary: Although the composition and assembly of stress granules (SGs) are well understood, the molecular mechanisms underlying SG disassembly remain unclear. Here, we identify that heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) is associated
Xiaoli Wang, Xu Fan, Jin Zhang, Fengli Wang, Jingshou Chen, Yujiao Wen, Lingjuan Wang, Tao Li, Huaibiao Li, Heng Gu, Youzhi Zhang, Shuiqiao Yuan   +11 more
doaj   +1 more source

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, Volume 9, Issue 12, December 2025.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Performances zootechniques des caprins nains (Capra aegagrus hircus) nourris à base de Panicum maximum et Pueraria phaseoloides

Revue Marocaine des Sciences Agronomiques et Vétérinaires
L’élevage des caprins nains en Afrique subsaharienne est très peu modernisé. Plusieurs facteurs zootechniques de production ne sont pas maîtrisés par les éleveurs.
Alex Stéphane Affian EMANFO, Kouamelan Jacques TCHINOU, Yatanan casimir BLE   +2 more
doaj   +1 more source

Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay   +4 more
wiley   +1 more source

RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins, Beatriz Barros‐Santos, Georgia Papadimitriou, Ioannis Sotiropoulos, Benjamin Wolozin, Joana Margarida Silva   +5 more
wiley   +1 more source