Results 51 to 60 of about 1,318 (123)
Advanced Science, Volume 13, Issue 6, 30 January 2026.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, Volume 9, Issue 12, December 2025.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors [PDF]
, 2019 K
Brown, Powel H. +15 more
core +1 more source
Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
FASEB BioAdvances, Volume 7, Issue 11, November 2025.Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur +4 more
wiley +1 more source
Cell ReportsSummary: Although the composition and assembly of stress granules (SGs) are well understood, the molecular mechanisms underlying SG disassembly remain unclear. Here, we identify that heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) is associated
Xiaoli Wang +11 more
doaj +1 more source
RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.Under physiological conditions, neuronal RNA granules (e.g., transport granules, activity‐dependent granules, processing bodies, and stress granules) cooperate to regulate mRNA transport, storage, and localized translation, thereby sustaining synaptic and neuronal functions.
Rita Nóbrega‐Martins +5 more
wiley +1 more source
Rakuvaba valgusünteesi rakendamine inimese neuroblastoomi SH-SY5Y rakuliinis [PDF]
, 2021 Bakalaureuse töö eesmärk oli luua inimese neuroblastoomi rakuliini SH-SY5Y kasutades mudelsüsteem erinevate RNA-d siduvate valkude ja komplekside uurimiseks, et neid oleks võimalik välja puhastada ja kasutada struktuuribioloogilistes uuringutes.
Liiv, Annika
core
Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules
Advanced Science, Volume 12, Issue 34, September 11, 2025.These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu +17 more
wiley +1 more source
Revue Marocaine des Sciences Agronomiques et VétérinairesL’élevage des caprins nains en Afrique subsaharienne est très peu modernisé. Plusieurs facteurs zootechniques de production ne sont pas maîtrisés par les éleveurs.
Alex Stéphane Affian EMANFO +2 more
doaj +1 more source
Recent Cutting‐Edge Technologies for the Delivery of Peptide Nucleic Acid
Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.This review provides an overview of PNA cellular delivery methods, starting with traditional peptide‐based systems and progressing to advanced approaches using nanoparticles, liposomes, and calixarene. It highlights how these innovative strategies have opened the way for more effective and efficient PNA delivery, ultimately enhancing the potential for ...
Concetta Avitabile +4 more
wiley +1 more source