Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH [PDF]
Open Biology, 2023 G3BP is the central node within stress-induced protein–RNA interaction networks known as stress granules (SGs). The SG-associated proteins Caprin-1 and USP10 bind mutually exclusively to the NTF2 domain of G3BP1, promoting and inhibiting SG formation ...
Tim Schulte, Marc D Panas, Xiao Han
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Caprin-1 influences autophagy-induced tumor growth and immune modulation in pancreatic cancer [PDF]
Journal of Translational Medicine, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is characterized by rapid progression and poor prognosis. Understanding the genetic mechanisms that affect cancer properties and reprogram tumor immune microenvironment will develop new strategies to ...
Le Li
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Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP [PDF]
Journal of Translational Medicine, 2023 Background Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is implicated in cancer cell proliferation and tumorigenesis; however, its role in the development of esophageal carcinoma (ESCA) has not been examined.
Zhi-Jun Pei
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β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1 [PDF]
Nature Communicationsβ-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder caused by mutations in the WDR45 gene, yet its molecular mechanisms remain poorly understood.
Yin Li +16 more
doaj +3 more sources
Radiopharmaceutical application of TRK-950, an anti-CAPRIN-1 therapeutic antibody [PDF]
Journal of Cancer Research and Clinical OncologyPurpose Tumor imaging or therapy using cancer specific carriers combined with a radioisotope has huge potential. In radiopharmaceutical development, it is important to ensure target specificity and minimal binding to normal tissues for both tumor ...
Yuki Majima +7 more
doaj +3 more sources
Yin and yang regulation of stress granules by Caprin-1 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Stress granules (SGs) are membraneless organelles regulating many vital biochemical processes. G3BP1 plays a critical role in regulating SG dynamics through its interaction with Caprin-1 and USP10.
Dan Song, Lin Yang, Lei Wang
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Can CAPRIN-1 Be Responsible for the Recurrence Potential of Odontogenic Keratocysts? [PDF]
eJournal of Oral Maxillofacial ResearchObjectives: The purpose of this retrospective study is to compare dentigerous cysts and odontogenic keratocysts for cytoplasmic activation/proliferation - associated protein-1 antibodies via immunohistochemical staining to obtain a new perspective about ...
Nelli Yildirimyan +2 more
doaj +3 more sources
RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response [PDF]
eLife, 2015 In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expression ...
Agnieszka Konopacka +4 more
doaj +6 more sources
Identification of Membrane-expressed CAPRIN-1 as a Novel and Universal Cancer Target, and Generation of a Therapeutic Anti-CAPRIN-1 Antibody TRK-950 [PDF]
Cancer Research Communications, 2023 Specific targets for cancer treatment are highly desirable, but still remain to be discovered. While previous reports suggested that CAPRIN-1 localizes in the cytoplasm, here we now show that part of this molecule is strongly expressed on the cell ...
Fumiyoshi Okano +2 more
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circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR [PDF]
Oncogene, 2023 Circular RNA (circRNA) is a novel RNA molecule characterized by covalently closed loop structure. Since its discovery, researchers have shown that circRNA is not “splicing noise” but a participant of various pathophysiological processes through unique ...
Jing Liu, Liling Niu, Yuan Yao
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